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Article Dans Une Revue BMC Medical Research Methodology Année : 2013

Using the random forest method to detect a response shift in the quality of life of multiple sclerosis patients: a cohort study

Mohamed Boucekine
  • Fonction : Auteur
Anderson Loundou
Karine Baumstarck
  • Fonction : Auteur
Patricia Minaya-Flores
  • Fonction : Auteur
Jean Pelletier
Badih Ghattas
Pascal Auquier
  • Fonction : Auteur

Résumé

Background Multiple sclerosis (MS), a common neurodegenerative disease, has well-described associations with quality of life (QoL) impairment. QoL changes found in longitudinal studies are difficult to interpret due to the potential response shift (RS) corresponding to respondents’ changing standards, values, and conceptualization of QoL. This study proposes to test the capacity of Random Forest (RF) for detecting RS reprioritization as the relative importance of QoL domains’ changes over time. Methods This was a longitudinal observational study. The main inclusion criteria were patients 18 years old or more with relapsing-remitting multiple sclerosis. Every 6 months up to month 24, QoL was recorded using generic and MS-specific questionnaires (MusiQoL and SF-36). At 24 months, individuals were divided into two ‘disability change’ groups: worsened and not-worsened patients. The RF method was performed based on Breiman’s description. Analyses were performed to determine which QoL scores of SF-36 predicted the MusiQoL index. The average variable importance (AVI) was estimated. Results A total of 417 (79.6%) patients were defined as not-worsened and 107 (20.4%) as worsened. A clear RS was identified in worsened patients. While the mental score AVI was almost one third higher than the physical score AVI at 12 months, it was 1.5 times lower at 24 months. Conclusion This work confirms that the RF method offers a useful statistical approach for RS detection. How to integrate the RS in the interpretation of QoL scores remains a challenge for future research.
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hal-03581987 , version 1 (23-10-2023)

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Mohamed Boucekine, Anderson Loundou, Karine Baumstarck, Patricia Minaya-Flores, Jean Pelletier, et al.. Using the random forest method to detect a response shift in the quality of life of multiple sclerosis patients: a cohort study. BMC Medical Research Methodology, 2013, 13 (1), pp.20. ⟨10.1186/1471-2288-13-20⟩. ⟨hal-03581987⟩
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