Knockout Myotonic dystrophy Endurance training Dynamin 2 Motoneuron Dilated cardiomyopathy Myelin Autophagy Glucocorticoid-receptor ACETYLCHOLINESTERASE DMPK Diaphragm PCR Heart failure Transgenic mouse DM1 Aging ARN Alternative splicing Myotonic Dystrophy Type 1 Gene therapy Astrocyte Trinucleotide Repeat Expansion Myostatin Heart CRISPRi Centronuclear myopathy Gene editing Antisense oligonucleotides Hypoxia Cardiac muscle Glial cells Skeletal muscle Dystrophin AAV CRISPR/Cas9 Glutamate Fibrosis In vivo Thérapie génique CTG repeat contractions MBNL Desmin Dystrophie Myotonique Acetylcholinesterase knockout mouse Myotonic dystrophy mouse models Mouse model Oligodendrocyte Trinucleotide repeat expansion CONGENITAL MYATHENIC SYNDROME Therapy Duchenne muscular dystrophy Astrocytes CTG repeats Neuron Brain Male Dystrophie myotonique PacBio Transgenic mouse model Exercice CMS Central nervous system Acute coronary syndrome RNA interference CTG repeat instability Intermediate filament Brain dysfunction Exercise GABA Cell penetrating peptide Oligodendrocytes Acetylcholinesterase deficiency BIOLOGIE MOLECULAIRE Muscle Animals Cytoskeleton Antisense oligonucleotide Cell model Maximal force Expression Glucocorticoids Humans Cell culture model Myotonic Dystrophy type 1 Gene Therapy Long read sequencing Muscular dystrophy GSK3␤ Myotonic dystrophy type 1 Mice Mouse models Genotype phenotype correlation DMSXL mice KNOCKOUT MICE Myotonic Dystrophy RNA biology Quantitative microdialysis RNA splicing Transcriptomics