New CT imaging method for adipose tissue analysis in mouse model of obesity
Résumé
In humans CT imaging is a validated method for the study of adipose tissue distribution and for quantification of visceral and subcutaneous fat. Equivalent methods adapted to murine models of obesity are still lacking. Indeed most attempts to quantify fat tissues in vivo, using dedicated small animal micro-CT, involve long-term X-ray exposure which limits longitudinal studies. We have overcome this limitation by using a human clinical CT which allows very fast 3D imaging and minimal radiation exposure for the study of adipose tissue distribution in mice in vivo. Moreover, we have developed an automatic image analysis method for the segmentation of Hounsfield units of adipose tissues and for the localization of abdominal regions of interest.
Origine | Fichiers produits par l'(les) auteur(s) |
---|