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Article Dans Une Revue EMBO Reports Année : 2012

Tie1 deficiency induces endothelial–mesenchymal transition

Résumé

Endothelial-mesenchymal transition (EndMT) has a significant role in embryonic heart formation and in various pathologies. However, the molecular mechanisms that regulate EndMT induction remain to be elucidated. We show that suppression of receptor tyrosine kinase Tie1 but not Tie2 induces human endothelial cells to undergo EndMT and that Slug deficiency reverts this process. We find that Erk1/2, Erk5 and Akt cascades control Slug promoter activity induced by Tie1 deficiency. Interestingly, EndMT is present in human pancreatic tumour. We propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours.

Dates et versions

hal-03562725 , version 1 (09-02-2022)

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Julie Garcia, Maria José Sandi, Pierre Cordelier, Bernard Binétruy, Jacques Pouysségur, et al.. Tie1 deficiency induces endothelial–mesenchymal transition. EMBO Reports, 2012, 13 (5), pp.431-439. ⟨10.1038/embor.2012.29⟩. ⟨hal-03562725⟩
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