CARBANIONIC DISPLACEMENT REACTIONS AT PHOSPHORUS: DIETHYL (2-PYRIDY L)METHYLPHOSPHONATE SYNTHESIS
Résumé
We describe the formation and reactions of the α-lithiated (2-pyridyl)methylphosphonate 1. The lithiated α-picoline is obtained by metallation in THF at low temperature with LDA (lithium diisopropylamide) (2 equiv.). This is then condensed with diethyl chlorophosphate. The thus-formed stable carbanion 1 reacts with various electrophiles: H 2 O, D 2 O, TMSCl, RX, and aldehydes in a Wittig-Horner reaction.
Domaines
Chimie organiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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