New route to 1-formylalkylphosphonates using diethyl trichloromethylphosphonate as a precursor
Résumé
Diethyl trichloromethylphosphonate 1 and chlorotrimethylsilane were converted in a threestep sequence by BuLi into α−phosphorylated α−silylated α−substituted carbanions 4. On reaction with ethyl formate in the presence of chlorotrimethylsilane they give transient silylated acetals 8 which are readily hydrolysed in acid medium into 1formylalkylphosphonates 7 which are isolated in good yields.
Domaines
Chimie organiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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