New route to amino[ 2 H 2 ]methylphosphonic acid via bis(trifluoroethyl) phosphonate transesterification
Résumé
Transesterification of bis(trifluoroethyl) chloromethyl- and azidomethyl-phosphonates with alcohols in the presence of catalytic quantities of alcoholates gives dialkyl chloromethyl- and azidomethyl-phosphonates in good yield. This process has been used for the synthesis of dibenzyl azido[2H2]methylphosphonate which has been reduced and hydrogenolised to amino[2H2]methylphosphonic acid under neutral conditions.
Origine | Fichiers produits par l'(les) auteur(s) |
---|