Preparation of alkyl- and aryl-amino[2H2]methylphosphinic acids
Résumé
Diethyl chloro[2H2]methylphosphonate upon successive treatment with POCl3 and Grignard reagents (RMgX) gave alkyl(chloro[2H2]methyl)phosphinates. Phenyl(chloro[2H2]methyl)phosphinate was prepared by deuteriolysis of the α-silylated α-phosphonylated carbanion 11 with D2O. After conversion into trifluoroethyl phosphinic esters, the alkyl- and phenyl-(chloro[2H2]methyl)phosphinates were converted into azides and then reduced and hydrogenated into alkyl- and phenyl-(amino[2H2]methyl)phosphinic acids.
Domaines
Chimie organiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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