A new route to α-fluorovinylphosphonates utilizing Peterson olefination methodology
Résumé
Several α-fluorovinylphosphonates (6) have been synthesised from the Peterson olefination reaction applied to both aldehydes and ketones in conjunction with α-lithiated-α-fluoro-αtrimethylsilylmethylphosphonate (2). The reaction with aldehydes gives mainly the E-isomer whereas reaction with ketones gives mainly the Z-isomer. We propose a closed transition state to explain the results of our study.
Domaines
Chimie organiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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