An Improved Synthesis of Dichloroalkylphosphonates, Chloroalkynes and Terminal Alkynes via Diethyl Dichloromethylphosphonate
Résumé
Diethyl 1,1-dichloromethylphosphonate (2) was synthesised in good yield from the reduction of 1,1,1-trichloromethylphosphonate (1) with i-C3H7MgCl and subsequent hydrolysis. The reactivity of 2 towards α-alkylation and its utility in the synthesis of chloroalkynes and terminal alkynes was investigated.
Domaines
Chimie organiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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