Normal immune system development in mice lacking the Deltex-1 RING finger domain. - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Biology Année : 2005

Normal immune system development in mice lacking the Deltex-1 RING finger domain.

Résumé

The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a RING finger ubiquitin ligase which is conserved from Drosophila to humans and has been proposed to be a regulator of Notch signaling. Its pattern of lymphoid expression as well as gain-of-function experiments suggest that Deltex-1 regulates both B-cell lineage and splenic marginal-zone B-cell commitment. Deltex-1 was also found to be highly expressed in germinal-center B cells. To investigate the physiological function of Deltex-1, we generated a mouse strain lacking the Deltex-1 RING finger domain, which is essential for its ubiquitin ligase activity. Deltex-1(Delta/Delta) mice were viable and fertile. A detailed histological analysis did not reveal any defects in major organs. T- and B-cell development was normal, as were humoral responses against T-dependent and T-independent antigens. These data indicate that the Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function. Possible compensatory mechanisms, in particular those from a fourth Deltex gene identified during the course of this study, are also discussed.
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hal-00165741 , version 1 (11-09-2008)

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Sébastien Storck, Frédéric Delbos, Nicolas Stadler, Catherine Thirion-Delalande, Florence Bernex, et al.. Normal immune system development in mice lacking the Deltex-1 RING finger domain.. Molecular and Cellular Biology, 2005, 25 (4), pp.1437-45. ⟨10.1128/MCB.25.4.1437-1445.2005⟩. ⟨hal-00165741⟩
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