A Dual Role for Actin and Microtubule Cytoskeleton in the Transport of Golgi Units from the Nurse Cells to the Oocyte Across Ring Canals. - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Molecular Biology of the Cell Année : 2008

A Dual Role for Actin and Microtubule Cytoskeleton in the Transport of Golgi Units from the Nurse Cells to the Oocyte Across Ring Canals.

Résumé

Monitoring Editor: Vivek Malhotra Axis specification during Drosophila embryonic development requires transfer of maternal components during oogenesis from nurse cells (NC) into the oocyte through cytoplasmic bridges. We found that the asymmetrical distribution of Golgi, between nurse cells and the oocyte, is sustained by an active transport process. We have caracterized actin basket structures that asymmetrically cap the NC side of Ring canals (RC) connecting the oocyte. Our results suggest that these actin baskets structurally support transport mechanisms of RC transit. In addition, our tracking analysis indicates that Golgi units are actively transported to the oocyte rather than diffusing. We observed that RC transit is microtubules-based and mediated at least by Dynein. Finally, we show that actin networks may be involved in RC cross-ing through a Myosin II step process, as well as in dispatching Golgi units inside the oocyte subcompartments.

Dates et versions

hal-00339162 , version 1 (17-11-2008)

Identifiants

Citer

Emmanuelle Nicolas, Nicolas Chenouard, Jean-Christophe Olivo-Marin, Antoine Guichet. A Dual Role for Actin and Microtubule Cytoskeleton in the Transport of Golgi Units from the Nurse Cells to the Oocyte Across Ring Canals.. Molecular Biology of the Cell, 2008, epub ahead of print. ⟨10.1091/mbc.E08-04-0360⟩. ⟨hal-00339162⟩
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