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Article Dans Une Revue Diabetes Année : 2010

Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha.

Résumé

These data demonstrate that beta-cell differentiation is controlled by pO2 through HIF1alpha. Modifying pO2 should now be tested in protocols aiming to differentiate beta-cells from embryonic stem cells.

Dates et versions

hal-00560065 , version 1 (27-01-2011)

Identifiants

Citer

Mylène Heinis, Marie-Thérèse Simon, Karine Ilc, Nathalie M Mazure, Jacques Pouysségur, et al.. Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha.. Diabetes, 2010, 59 (3), pp.662-9. ⟨10.2337/db09-0891⟩. ⟨hal-00560065⟩
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