Does Depression Predict Coronary Heart Disease and Cerebrovascular Disease Equally Well? The HeSSup Prospective Cohort Study - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue International Journal of Epidemiology Année : 2010

Does Depression Predict Coronary Heart Disease and Cerebrovascular Disease Equally Well? The HeSSup Prospective Cohort Study

Résumé

Background: The relationship between depression and cerebrovascular disease (CBVD) continues to be debated although little research has compared the predictive power of depression for coronary heart disease (CHD) to that for CBVD within the same population. This study aimed to compare the importance of depression for CHD and CBVD within the same population of adults free of apparent cardiovascular disease. Methods: A random sample of 23282 adults (9507 men, 13775 women) aged 20-54 years were followed-up for 7 years. Fatal and first non-fatal CHD and CBVD events were documented by linkage to the National-hospital-discharge and mortality registers. Results: Sex-age-education-adjusted Hazard Ratio (HR) for CHD was 1.66 (95% confidence interval (CI) 1.24-2.24) for participants with mild to severe depressive symptoms, i.e. those scoring 10 or more on the 21-item Beck-Depression-Inventory, and 2.04 (1.27-3.27) for those who filled antidepressant prescriptions compared to those without depression markers in 1998, i.e., at study baseline. For CBVD, the corresponding HRs were 1.01 (0.67-1.53) and 1.77 (0.95-3.29). After adjustment for behavioural and biological risk factors these associations were reduced but remained evident for CHD, the adjusted HRs being 1.47 (1.08-1.99) and 1.72 (1.06-2.77). For CBVD, the corresponding multivariable adjusted HRs were 0.87 (0.57-1.32) and 1.52 (0.81-2.84). Conclusions: Self-reported depression using a standardized questionnaire and clinical markers of mild to severe depression were associated with an increased risk for CHD. There was no clear evidence that depression is a risk factor for CBVD, but this needs further confirmation.

Mots clés

Fichier principal
Vignette du fichier
PEER_stage2_10.1093%2Fije%2FDYQ050.pdf (190.08 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00581854 , version 1 (01-04-2011)

Identifiants

Citer

Hermann Nabi, Mika Kivimaki, Sakari Suominen, Markku Koskenvuo, Archana Singh-Manoux, et al.. Does Depression Predict Coronary Heart Disease and Cerebrovascular Disease Equally Well? The HeSSup Prospective Cohort Study. International Journal of Epidemiology, 2010, ⟨10.1093/ije/DYQ050⟩. ⟨hal-00581854⟩
198 Consultations
69 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More