Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2010

Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient.

Florence Chapeland-Leclerc
Christophe Hennequin
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Nicolas Papon
Aurélie Girard
  • Fonction : Auteur
Gérard Socié
Claire Lacroix
  • Fonction : Auteur

Résumé

We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.

Dates et versions

hal-00594730 , version 1 (20-05-2011)

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Citer

Florence Chapeland-Leclerc, Christophe Hennequin, Nicolas Papon, Thierry Noël, Aurélie Girard, et al.. Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient.. Antimicrobial Agents and Chemotherapy, 2010, 54 (3), pp.1360-2. ⟨10.1128/AAC.01138-09⟩. ⟨hal-00594730⟩
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