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Article Dans Une Revue Journal of Clinical Periodontology Année : 2012

Salivary proteome modifications associated with periodontitis in obese patients.

Résumé

AIM: To identify changes in the salivary protein/peptide profiles by differential proteomics in obese patients with or without periodontitis. MATERIAL AND METHODS: Periodontal examinations and whole saliva samples were obtained from 38 obese patients (mean age: 45.1 ± 7.3 years, mean BMI: 49.3 ± 9 kg/m(2) ) including 13 periodontitis and 25 non-periodontitis subjects, and 19 healthy controls (mean age: 44.2 ± 6.4 years, mean BMI: 21.5 ± 2.1 kg/m(2) ). Surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry (MS) was used to compare the whole saliva polypeptide profiles. RESULTS: The SELDI-TOF-MS analysis detected eight putative markers. Six of them were increased and identified in obese subjects versus controls (albumin, α and β haemoglobin chains, α-defensins 1, 2 and 3). Alpha-defensins were less abundant in saliva of periodontitis obese patients (36.47 ± 19.84 μA) versus non-periodontitis obese patients (43.44 ± 30.34 μA), whereas α-defensins were more abundant in obese patients (40.99 ± 26.66 μA) versus controls (27.1 ± 23.98 μA). CONCLUSIONS: Periodontal status modifies the salivary proteome in obese patients. Alpha-defensins may play a role in gingival inflammation, and be involved in the higher susceptibility of obese patients to periodontal diseases.

Dates et versions

hal-00763783 , version 1 (11-12-2012)

Identifiants

Citer

Hélène Rangé, Thibaut Léger, Clarisse Huchon, Cécile Ciangura, Devy Diallo, et al.. Salivary proteome modifications associated with periodontitis in obese patients.. Journal of Clinical Periodontology, 2012, 39 (9), pp.799-806. ⟨10.1111/j.1600-051X.2012.01913.x⟩. ⟨hal-00763783⟩
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