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Article Dans Une Revue International Journal of Pharmaceutics Année : 2013

Development of a percutaneous penetration predictive model by SR-FTIR

Résumé

This work focused on developing a new evaluation criterion of percutaneous penetration, in complement to Log Pow and MW and based on high spatial resolution Fourier transformed infrared (FTIR) microspectroscopy with a synchrotron source (SR-FTIR). Classic Franz cell experiments were run and after 22 h molecule distribution in skin was determined either by HPLC or by SR-FTIR. HPLC data served as reference. HPLC and SR-FTIR results were compared and a new predictive criterion based from SR-FTIR results, named S-index, was determined using a multi-block data analysis technique (ComDim). A predictive cartography of the distribution of molecules in the skin was built and compared to OECD predictive cartography. This new criterion S-index and the cartography using SR-FTIR/HPLC results provides relevant information for risk analysis regarding prediction of percutaneous penetration and could be used to build a new mathematical model. (C) 2012 Elsevier B. V. All rights reserved.

Dates et versions

hal-01019096 , version 1 (07-07-2014)

Identifiants

Citer

E. Jungman, C. Laugel, Douglas N. Rutledge, P. Dumas, A. Baillet-Guffroy. Development of a percutaneous penetration predictive model by SR-FTIR. International Journal of Pharmaceutics, 2013, 441 (1-2), pp.628 - 635. ⟨10.1016/j.ijpharm.2012.10.034⟩. ⟨hal-01019096⟩
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