Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection. - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Immunity Année : 2002

Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.

Résumé

Cytomegalovirus (CMV) infection is characterized by host immunosuppression and multiorganic involvement. CMV-infected dendritic cells (DC) were recently shown to display reduced immune functions, but their role in virus dissemination is not clear. In this report, we demonstrated that CMV could be captured by DC through binding on DC-SIGN and subsequently transmitted to permissive cells. Moreover, blocking DC-SIGN by specific antibodies inhibited DC infection by primary CMV isolates and expression of DC-SIGN or its homolog DC-SIGNR rendered susceptible cells permissive to CMV infection. We demonstrated that CMV envelope glycoprotein B is a viral ligand for DC-SIGN and DC-SIGNR. These results provide new insights into the molecular interactions contributing to cell infection by CMV and extend DC-SIGN implication in virus propagation.

Mots clés

Dates et versions

hal-01061427 , version 1 (05-09-2014)

Identifiants

Citer

Franck Halary, Ali Amara, Hugues Lortat-Jacob, Martin Messerle, Thierry Delaunay, et al.. Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.. Immunity, 2002, 17 (5), pp.653-64. ⟨10.1016/S1074-7613(02)00447-8⟩. ⟨hal-01061427⟩
409 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More