Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity. - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Journal of Neuroscience Année : 2012

Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.

Résumé

Understanding how brief synaptic events can lead to sustained changes in synaptic structure and strength is a necessary step in solving the rules governing learning and memory. Activation of ERK1/2 (extracellular signal regulated protein kinase 1/2) plays a key role in the control of functional and structural synaptic plasticity. One of the triggering events that activates ERK1/2 cascade is an NMDA receptor (NMDAR)-dependent rise in free intracellular Ca(2+) concentration. However the mechanism by which a short-lasting rise in Ca(2+) concentration is transduced into long-lasting ERK1/2-dependent plasticity remains unknown. Here we demonstrate that although synaptic activation in mouse cultured cortical neurons induces intracellular Ca(2+) elevation via both GluN2A and GluN2B-containing NMDARs, only GluN2B-containing NMDAR activation leads to a long-lasting ERK1/2 phosphorylation. We show that αCaMKII, but not βCaMKII, is critically involved in this GluN2B-dependent activation of ERK1/2 signaling, through a direct interaction between GluN2B and αCaMKII. We then show that interfering with GluN2B/αCaMKII interaction prevents synaptic activity from inducing ERK-dependent increases in synaptic AMPA receptors and spine volume. Thus, in a developing circuit model, the brief activity of synaptic GluN2B-containing receptors and the interaction between GluN2B and αCaMKII have a role in long-term plasticity via the control of ERK1/2 signaling. Our findings suggest that the roles that these major molecular elements have in learning and memory may operate through a common pathway.

Domaines

Neurobiologie
Fichier non déposé

Dates et versions

hal-01284778 , version 1 (08-03-2016)

Identifiants

  • HAL Id : hal-01284778 , version 1
  • PUBMED : 22855824

Citer

Farida El Gaamouch, Alain Buisson, Olivier Moustié, Mado Lemieux, Simon Labrecque, et al.. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.. Journal of Neuroscience, 2012, 32 (31), pp.10767-79. ⟨hal-01284778⟩
61 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More