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Article Dans Une Revue Genome Biology and Evolution Année : 2016

The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-component and Metazoan-type Tyrosine Kinase Signaling

Narie Sasaki
  • Fonction : Auteur
Xiao Chen
  • Fonction : Auteur
Chrystelle Maric
Rob Peace
  • Fonction : Auteur
Taeko Sasaki
  • Fonction : Auteur
Reema Singh
  • Fonction : Auteur
Takamasa Suzuki

Résumé

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
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hal-01291681 , version 1 (21-03-2016)

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Pauline Schaap, Israel Barrantes, Pat Minx, Narie Sasaki, Roger W. Anderson, et al.. The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-component and Metazoan-type Tyrosine Kinase Signaling. Genome Biology and Evolution, 2016, 8 (1), pp.109-125. ⟨10.1093/gbe/evv237⟩. ⟨hal-01291681⟩
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