Resistant depression : potentiation strategies - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue La Presse Médicale Année : 2016

Resistant depression : potentiation strategies

Olivier Doumy
  • Fonction : Auteur
Remy Bation
  • Fonction : Auteur
Frank Bellivier
Jerome Holtzmann
  • Fonction : Auteur
Vincent Camus
Marion Garnier
  • Fonction : Auteur
Frederic Haesebaert
  • Fonction : Auteur
Fanny Moliere
  • Fonction : Auteur
Isabel Nieto
  • Fonction : Auteur
Guillaume Vaiva
Pierre-Michel Llorca

Résumé

Lithium is among the most classically recommended add-on therapeutic ă strategy for the management of depressive patients showing unsuccessful ă response to standard antidepressant medications. ă The effectiveness of the add-on strategy with lithium requires achieving ă plasma levels above 0.5 mEq/L. ă Mood-stabilizing antiepileptic drugs such as carbamazepine, valproate ă derivatives or lamotrigine have not demonstrated conclusive therapeutic ă effects for the management of depressive patients showing unsuccessful ă response to standard antidepressant medications. ă Thyroid hormones are considered among the currently recommended add-on ă therapeutic strategy for the management of depressive patients showing ă unsuccessful response to standard antidepressant medications. ă The effectiveness of the add-on strategy with thyroid hormones requires ă achieving plasma concentration of TSH close to the lower limits at the ă normal range (0.4 mUI/L) or even below it. Second-generation ă antipsychotics such as aripiprazole or quetiapine have consistently ă demonstrated significant therapeutic effects for the management of ă depressive patients showing unsuccessful response to standard ă antidepressant medications. ă Second-generation antipsychotics however require the careful monitoring ă of both cardiovascular and metabolic adverse effects.
Fichier non déposé

Dates et versions

hal-01482633 , version 1 (03-03-2017)

Identifiants

Citer

Olivier Doumy, Djamila Bennabi, Wissam El-Hage, Najib Allaïli, Remy Bation, et al.. Resistant depression : potentiation strategies. La Presse Médicale, 2016, 45 (3), pp.338-349. ⟨10.1016/j.lpm.2016.02.004⟩. ⟨hal-01482633⟩
368 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More