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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2016

Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection

Sean Kennedy
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Pascale Cossart

Résumé

Listeria monocytogenes is responsible for gastroenteritis in healthy individuals and for a severe invasive disease in immunocompromised patients. Among the three identified L. monocytogenes evolutionary lineages, lineage I strains are overrepresented in epidemic listeriosis outbreaks, but the mechanisms underlying the higher virulence potential of strains of this lineage remain elusive. Here, we demonstrate that Listeriolysin S (LLS), a virulence factor only present in a subset of lineage I strains, is a bacteriocin highly expressed in the intestine of orally infected mice that alters the host intestinal microbiota and promotes intestinal colonization by L. monocytogenes, as well as deeper organ infection. To our knowledge, these results therefore identify LLS as the first bacteriocin described in L. monocytogenes and associate modulation of host microbiota by L. monocytogenes epidemic strains to increased virulence.

Dates et versions

hal-01533881 , version 1 (06-06-2017)

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Juan J. Quereda, Olivier Dussurget, Marie-Anne Nahori, Amine Ghozlane, Stevenn Volant, et al.. Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (20), pp.5706 - 5711. ⟨10.1073/pnas.1523899113⟩. ⟨hal-01533881⟩
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