%0 Journal Article %T Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging %+ Institut Langevin - Ondes et Images (UMR7587) (IL) %+ Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970) %+ Université Paris Descartes - Faculté de Médecine (UPD5 Médecine) %+ Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC) %+ CHU Pitié-Salpêtrière [AP-HP] %+ Equipe “Contrôle Métabolique des Morts Cellulaires” (INSERM U1065 - C3M) %+ Institut de Recherche sur le Cancer et le Vieillissement (IRCAN) %+ Département de Biologie Médicale [Centre Scientifique de Monaco] %+ Département de Radiologie Cardiovasculaire [AP-HP Hôpital Européen Georges Pompidou] %A Provost, Jean %A Garofalakis, Anikitos %A Sourdon, Joevin %A Bouda, Damien %A Berthon, Béatrice %A Viel, Thomas %A Perez-Liva, Mailyn %A Lussey-Lepoutre, Charlotte %A Favier, Judith %A Correia, Mafalda %A Pernot, Mathieu %A Chiche, Johanna %A Pouysségur, Jacques %A Tanter, Mickaël %A Tavitian, Bertrand %< avec comité de lecture %@ 2157-846X %J Nature Biomedical Engineering %I Nature Publishing Group %V 2 %P 85-94 %8 2018 %D 2018 %R 10.1038/s41551-018-0188-z %Z Life Sciences [q-bio]/Bioengineering/ImagingJournal articles %X Positron emission tomography–computed tomography (PET–CT) is the most sensitive molecular imaging modality, but it does not easily allow for rapid temporal acquisition. Ultrafast ultrasound imaging (UUI)—a recently introduced technology based on ultrasonic holography—leverages frame rates of up to several thousand images per second to quantitatively map, at high resolution, haemodynamic, biomechanical, electrophysiological and structural parameters. Here, we describe a pre-clinical scanner that registers PET–CT and UUI volumes acquired simultaneously and offers multiple combinations for imaging. We demonstrate that PET–CT–UUI allows for simultaneous images of the vasculature and metabolism during tumour growth in mice and rats, as well as for synchronized multi-modal cardiac cine-loops. Combined anatomical, functional and molecular imaging with PET–CT–UUI represents a high-performance and clinically translatable technology for biomedical research. %G English %2 https://u-paris.hal.science/hal-01864270/document %2 https://u-paris.hal.science/hal-01864270/file/Tavitian_AR_1518186714_1.pdf %L hal-01864270 %U https://u-paris.hal.science/hal-01864270 %~ INSERM %~ UNICE %~ UNIV-PARIS5 %~ ESPCI %~ CNRS %~ APHP %~ PARISTECH %~ IL %~ LANGEVIN %~ PSL %~ USPC %~ UNIV-COTEDAZUR %~ CHU-UNIV-PARIS5 %~ SORBONNE-UNIVERSITE %~ SORBONNE-UNIV %~ SU-MEDECINE %~ SU-SCIENCES %~ SU-MED %~ UNIV-PARIS %~ UP-SANTE %~ UP-SCIENCES %~ TEST-HALCNRS %~ ESPCI-PSL %~ SU-TI %~ ANR %~ ALLIANCE-SU %~ C3M %~ IRCAN %~ TEST3-HALCNRS