Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Psychopharmacology Année : 2014

Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties

Joël Schlatter

Résumé

Transport across the BBB is a determinant of the rate and extent of drug distribution in the brain. Heroin exerts its effects through its principal metabolites 6-monoacetyl-morphine (6-MAM) and morphine. Morphine is a known substrate of P-glycoprotein (P-gp) at the blood-brain-barrier (BBB) however, little is known about the interaction of heroin and 6-MAM with P-gp.
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hal-01904771 , version 1 (29-10-2022)

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Maria Seleman, Hélène Chapy, Salvatore Cisternino, Cindie Courtin, Maria Smirnova, et al.. Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties. Psychopharmacology, 2014, 231 (16), pp.3139 - 3149. ⟨10.1007/s00213-014-3490-9⟩. ⟨hal-01904771⟩
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