Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Cell Reports Année : 2014

Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels

Résumé

Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation or voltage-dependence. We examined nine different mutations of the KCNT1 (Slack) Na +-activated K + channel that give rise to three distinct forms of epilepsy. All produced many fold-increases in current amplitude over that of the wild type channel. This could Author Contributions GEK designed and performed whole-oocyte electrophysiological and Western blot experiments; JK designed and performed single channel electrophysiological experiments; GB and HCM performed mutational analysis of patients' DNA samples; IHQ performed electrophysiological experiments; LC performed mutagenesis experiments; EB, JCT, OD and RN supervised clinical portions of the study; LKK supervised the electrophysiological experiments; GEK, JK, RN and LKK jointly wrote the manuscript. NIH Public Access
Fichier principal
Vignette du fichier
KCNT1 Cell Report 2014.pdf (697.05 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02044797 , version 1 (21-02-2019)

Identifiants

Citer

Grace E Kim, Jack Kronengold, Giulia Barcia, Imran H Quraishi, Hilary C Martin, et al.. Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels. Cell Reports, 2014, 9 (5), pp.1661-1672. ⟨10.1016/j.celrep.2014.11.015⟩. ⟨hal-02044797⟩
28 Consultations
59 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More