On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2007

On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition

Résumé

Cyclic peptides were obtained, on-resin, by the copper (I) catalysed 1,3-dipolar cycloaddition of azides and alkynes. The reaction led exclusively to the formation of the expected cyclomonomeric products which acted as ligands of the Vascular Endothelial Growth Factor receptor 1.

Dates et versions

hal-02122521 , version 1 (07-05-2019)

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Victor Goncalves, Benoît Gautier, Anne Regazzetti, Pascale Coric, Serge Bouaziz, et al.. On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition. Bioorganic and Medicinal Chemistry Letters, 2007, 17 (20), pp.5590-5594. ⟨10.1016/j.bmcl.2007.07.087⟩. ⟨hal-02122521⟩
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