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Article Dans Une Revue Epilepsia Année : 2018

Altered vaccine-induced immunity in children with Dravet syndrome

Résumé

Dravet syndrome (DS) is a refractory epileptic syndrome. Vaccination is the trigger of the first seizure in about 50% of cases. Fever remains a trigger of seizures during the course of the disease. We compared ex vivo cytokine responses to a combined aluminium-adjuvanted vaccine of children with DS to sex-and age-matched heathy children. Using ex vivo cytokine responses of peripheral-blood mononuclear cells and monocytes, we found that vaccine responsiveness is biased toward a proinflammatory profile in DS with a M1 phenotype of monocytes. We provide new insight into immune mechanisms associated with DS that might guide research for the development of new immunotherapeutic agents in this epilepsy syndrome.
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Dates et versions

hal-02357179 , version 1 (09-11-2019)

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Stéphane Auvin, Mohamed Jeljeli, Béatrice Desnous, Nadia Soussi-Yanicostas, Pascal Dournaud, et al.. Altered vaccine-induced immunity in children with Dravet syndrome. Epilepsia, 2018, 59 (4), pp.e45-e50. ⟨10.1111/epi.14038⟩. ⟨hal-02357179⟩
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