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Article Dans Une Revue Hematological Oncology Année : 2019

Aggressive large B‐cell lymphoma triggered by a parvovirus B19 infection in a previously healthy child

Résumé

In absence of red blood cells disease or immune defect, parvovirus B19 (PVB-19) is usually considered as a benign condition. Here, we report the case of a 10-year-old boy, previously healthy, presenting with a PVB-19 infection revealed by a bicytopenia and a voluminous axillary adenopathy. Pathophysiology examination showed reactional lymphoid population. Nine months later and in the absence of remission, a new biopsy of the same adenopathy revealed a Hodgkin lymphoma with area of T-cell rich aggressive large B-cell lymphoma. This case suggests PVB-19 as potential trigger of this malignant childhood hemopathy. Although no definitive conclusion can be drawn, our clinical case questions the role of PVB-19 in lymphomagenesis.

Domaines

Immunologie
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Dates et versions

hal-02392025 , version 1 (03-12-2019)

Identifiants

Citer

Laura Olivier-Gougenheim, Frédérique Dijoud, Alexandra Traverse-Glehen, Sarah Benezech, Yves Bertrand, et al.. Aggressive large B‐cell lymphoma triggered by a parvovirus B19 infection in a previously healthy child. Hematological Oncology, 2019, 37 (4), pp.483-486. ⟨10.1002/hon.2665⟩. ⟨hal-02392025⟩
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