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Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2019

Distinctive Krebs cycle remodeling in iPSC-derived neural and mesenchymal stem cells

Résumé

Mitochondria play a vital role in proliferation and differentiation and their remodeling in the course of differentiation is related to the variable energy and metabolic needs of the cell. In this work, we show a distinctive mitochondrial remodeling in human induced pluripotent stem cells differentiated into neural or mesenchymal progenitors. While leading to upregulation of the slow-running segment of the Krebs cycle and increased respiratory chain activities and respiration in the mesenchymal stem cells, the metabolic switch in the neural stem cells resulted in downregulation of α-ketoglutarate dehydrogenase and upregulation of isocitrate dehydrogenase 2 concomitant with the accumulation of α-ketoglutarate. The distinct, lineagespecific changes indicate an involvement of these Krebs cycle enzymes in cell differentiation.
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Dates et versions

hal-02414270 , version 1 (06-01-2021)

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Sarah Benlamara, Laetitia Aubry, Julien Fabregue, Paule Bénit, Pierre Rustin, et al.. Distinctive Krebs cycle remodeling in iPSC-derived neural and mesenchymal stem cells. Biochemical and Biophysical Research Communications, 2019, 511 (3), pp.658-664. ⟨10.1016/j.bbrc.2019.02.033⟩. ⟨hal-02414270⟩
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