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Article Dans Une Revue Adipocyte Année : 2020

Antibody-mediated neutralization of ACBP/DBI has anorexigenic and lipolytic effects

Résumé

We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel 'hunger factor': a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and obesity. Conversely, neutralization of ACBP/DBI by systemic injection of neutralizing monoclonal antibodies or autoantibodies produced after auto-immunization against ACBP/DBI has anorexigenic and lipolytic effects. Thus, neutralization of ACBP/DBI results in reduced food intake subsequent to the activation of anorexigenic neurons and the inactivation of orexigenic neurons in the hypothalamus. Moreover, ACBP/DBI neutralization results into enhanced triglyceride lipolysis in white fat, a surge in free fatty acids in the plasma, enhanced incorporation of glycerol-derived carbon atoms into glucose, as well as an increase in β-oxidation, resulting in a net reduction of fat mass. Importantly, ACBP/DBI neutralization also stimulated an increase in autophagy in various organs, suggesting that it might mediate anti-ageing effects.
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Dates et versions

hal-02537169 , version 1 (08-04-2020)

Identifiants

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Valentina Sica, Isabelle Martins, Omar Motiño, José Bravo-San Pedro, Guido Kroemer. Antibody-mediated neutralization of ACBP/DBI has anorexigenic and lipolytic effects. Adipocyte, 2020, 9 (1), pp.116-119. ⟨10.1080/21623945.2020.1736734⟩. ⟨hal-02537169⟩
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