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Article Dans Une Revue PLoS Genetics Année : 2011

A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

James D. Mckay (1) , - Therese Truong (1) , Valerie Gaborieau (1) , Amélie Chabrier (1) , Shu-Chun Chuang (1) , Graham Byrnes (1) , David Zaridze (2) , Oxana Shangina (2) , Neonila Szeszenia-Dabrowska (3) , Jolanta Lissowska (4) , Peter Rudnai (5) , Eleonora Fabianova (6) , Alexandru Bucur (7) , Vladimir Bencko (8) , Ivana Holcatova (8) , Vladimir Janout (9) , Lenka Foretova (10) , Pagona Lagiou (11) , Dimitrios Trichopoulos (11, 12) , Simone Benhamou (13, 14) , Christine Bouchardy (15) , Wolfgang Ahrens (16) , Franco Merletti (17) , Lorenzo Richiardi (17) , Renato Talamini (18) , Luigi Barzan (19) , Kristina Kjaerheim (20) , Gary J. Macfarlane (21) , Tatiana V. Macfarlane (21) , Lorenzo Simonato (22) , Cristina Canova (22, 23) , Antonio Agudo (24) , Xavier Castellsagué (24, 25) , Ray Lowry (26) , David I. Conway (27) , Patricia A. Mckinney (28, 29) , Claire M. Healy (30) , Mary E. Toner (30) , Ariana Znaor (31) , Maria Paula Curado (1) , Sergio Koifman (32) , Ana Menezes (33) , Victor Wüensch-Filho (34) , José Eluf Neto (34) , Leticia Fernandez Garrote (35) , Stefania Boccia (36) , Gabriella Cadoni (37) , Dario Arzani (37) , Andrew F. Olshan (38) , Mark C. Weissler (38) , William K. Funkhouser (38) , Jingchun Luo (38) , Jan Lubinski (39) , Joanna Trubicka (39) , Marcin Lener (39) , Dorota Oszutowska (39) , Stephen M. Schwartz (40) , Chu Chen (40) , Sherianne Fish (40) , David R. Doody (40) , Joshua E. Muscat (41) , Philip Lazarus (41) , Carla J. Gallagher (41) , Shen-Chih Chang (42) , Zuo-Feng Zhang (42) , Qingyi Wei (43) , Erich M. Sturgis (43) , Li-E Wang (43) , Silvia Franceschi (1) , Rolando Herrero (44) , Karl T. Kelsey (45) , Michael D. Mcclean (46) , Carmen J. Marsit (45) , Heather H. Nelson (47) , Marjorie Romkes (48) , Shama Buch (48) , Tomoko Nukui (48) , Shilong Zhong (48) , Martin Lacko (49) , Johannes J. Manni (49) , Wilbert H. M. Peters (50) , Rayjean J. Hung (51) , John Mclaughlin (52) , Lars Vatten (53) , Inger Njolstad (54) , Gary E. Goodman (40) , John K. Field (55) , Triantafillos Liloglou (55) , Paolo Vineis (56, 57) , Françoise Clavel-Chapelon (58) , Domenico Palli (59) , Rosario Tumino (60) , Vittorio Krogh (18) , Salvatore Panico (61) , Carlos A. Gonzalez , J. Ramon Quirós , Carmen Martinez , Carmen Navarro , Eva Ardanaz , Nerea Larrañaga , Kay-Tee Khaw , Timothy Key , H. Bas Bueno-De-Mesquita , Petra H. M. Peeters , Antonia Trichopoulou , Jakob Linseisen , Heiner Boeing , Göran Hallmans , Kim Overvad , Anne Tjonneland , Merethe Kumle , Elio Riboli , Kristjan Vaelk , Tonu Voodern , Andres Metspalu , Paul Brennan , Diana Zelenika , Anne Boland , Marc Delepine , Mario Foglio , Doris Lechner , Hélène Blanché , Ivo G. Gut , Pilar Galan (62) , Simon Heath , Mia Hashibe , Richard B. Hayes , Paolo Boffetta , Mark Lathrop
1 IARC - International Agency for Research on Cancer
2 Russian Academy of Medical Sciences
3 Department of Epidemiology
4 Maria Skłodowska Curie Memorial Cancer Center
5 National Institute for Environment
6 Regional Authority of Public Health
7 Institute of Public Health
8 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
9 Palacky University Olomouc
10 Department of Cancer Epidemiology and Genetics
11 NKUA - National and Kapodistrian University of Athens
12 Department of Epidemiology
13 U946 - Variabilité Génétique et Maladies Humaines
14 UMR 8200 - Stabilité Génétique et Oncogenèse
15 UNIGE - Université de Genève = University of Geneva
16 Bremen Institute for Prevention Research and Social Medicine (BIPS)
17 Universita di Torino
18 IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico
19 General Hospital
20 Cancer Registry of Norway
21 School of Medicine and Dentistry
22 Unipd - Università degli Studi di Padova = University of Padua
23 Imperial College London
24 ICO - Catalan Institute of Oncology = Instituto Catalán de Oncología
25 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
26 Newcastle University [Newcastle]
27 Dental School
28 Centre for Epidemiology and Biostatistics
29 NHS NSS ISD
30 School of Dental Science
31 National Institute of Public Health
32 National School of Public Health
33 UFPel - Universidade Federal de Pelotas = Federal University of Pelotas
34 USP - Universidade de São Paulo = University of São Paulo
35 Institute of Oncology and Radiobiology
36 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
37 Institute of Hygiene
38 University of North Carolina
39 PUM - Pomeranian Medical University [Szczecin]
40 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
41 Penn State College of Medicine
42 UCLA - University of California [Los Angeles]
43 Anderson Cancer Center
44 Instituto de Investigación Epidemiológica
45 Brown University
46 School of public health
47 Masonic Cancer Center
48 DEPARTMENT OF MATHEMATICS - University of Pittsburgh
49 Maastricht University [Maastricht]
50 Radboud University Medical Center [Nijmegen]
51 MSH - Mount Sinai Hospital [Toronto, Canada]
52 Cancer Care Ontario
53 NTNU - Norwegian University of Science and Technology
54 UiT - University of Tromsø
55 University of Liverpool
56 CPO Piemonte - Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in Piemonte = Center for Cancer Prevention-Piemonte
57 Department of Epidemiology and Public Health
58 INSERM - Institut National de la Santé et de la Recherche Médicale
59 Istituto per lo Studio e la Prevezione Oncologica
60 Civile - M.P.Arezzo Hospital
61 Department of Clinical and Experimental Medicine
62 UREN - Unité de Recherche en Epidémiologie Nutritionnelle
Luigi Barzan
  • Fonction : Auteur
David I. Conway
  • Fonction : Auteur
Li-E Wang
  • Fonction : Auteur
Karl T. Kelsey
  • Fonction : Auteur
Rosario Tumino
Carlos A. Gonzalez
  • Fonction : Auteur
J. Ramon Quirós
  • Fonction : Auteur
Carmen Martinez
  • Fonction : Auteur
Carmen Navarro
  • Fonction : Auteur
Eva Ardanaz
  • Fonction : Auteur
Nerea Larrañaga
  • Fonction : Auteur
Kay-Tee Khaw
  • Fonction : Auteur
Timothy Key
  • Fonction : Auteur
H. Bas Bueno-De-Mesquita
  • Fonction : Auteur
Petra H. M. Peeters
  • Fonction : Auteur
Antonia Trichopoulou
  • Fonction : Auteur
Jakob Linseisen
  • Fonction : Auteur
Heiner Boeing
  • Fonction : Auteur
Göran Hallmans
  • Fonction : Auteur
Kim Overvad
  • Fonction : Auteur
Anne Tjonneland
  • Fonction : Auteur
Merethe Kumle
  • Fonction : Auteur
Elio Riboli
Kristjan Vaelk
  • Fonction : Auteur
Tonu Voodern
  • Fonction : Auteur
Andres Metspalu
  • Fonction : Auteur
Paul Brennan
  • Fonction : Auteur
Diana Zelenika
  • Fonction : Auteur
Anne Boland
Marc Delepine
  • Fonction : Auteur
Mario Foglio
  • Fonction : Auteur
Doris Lechner
  • Fonction : Auteur
Hélène Blanché
Ivo G. Gut
  • Fonction : Auteur
Simon Heath
  • Fonction : Auteur
Mia Hashibe
  • Fonction : Auteur
Richard B. Hayes
  • Fonction : Auteur
Paolo Boffetta
  • Fonction : Auteur
Mark Lathrop
  • Fonction : Auteur

Résumé

Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p <= 5 x 10(-7)). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1 x 10(-8)) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2 x 10(-8)) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 x 10(-8); rs1229984-ADH1B, p = 7 x 10(-9); and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
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Dates et versions

hal-02650683 , version 1 (29-05-2020)

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James D. Mckay, - Therese Truong, Valerie Gaborieau, Amélie Chabrier, Shu-Chun Chuang, et al.. A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium. PLoS Genetics, 2011, 7 (3), ⟨10.1371/journal.pgen.1001333⟩. ⟨hal-02650683⟩
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