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Poster De Conférence Année : 2017

Nutrition and cancer in primary prevention: new insights from circadian regulation

Résumé

Background and objectives: Circadian disruption, resulting from shiftwork, has been classified as probably carcinogenic to humans by the International Agency for Research on Cancer. The biological circadian clock is subject to environmental effects, particularly light exposure and rhythmic food intake. However, the association between circadian nutritional behaviors and cancers has never been well explored. We investigated the prospective associations between time of the last eating episode, number of eating episodes, night-time fasting duration and the nutritional quality of the last eating episode, with overall, breast and prostate cancer risks. Methods: This prospective study included 41,389 men and women of the French population-based NutriNet-Santé cohort (2009-2016) who completed at least three 24h-dietary records during the first two years of follow-up. The risk of developing cancer was compared across different groups using multivariable Cox models. Results: 1,732 first primary incident cancer cases were diagnosed during follow-up, among which 428 breast cancers and 179 prostate cancers. Late eaters (last eating episode after 9:30 pm) had an increased risk of breast cancer (HR=1.48 (1.02-2.17), p=0.03) and prostate cancer (HR=2.20 (1.28-3.78), p=0.004); on the other hand, early eaters (last eating episode before 7 pm) had a lower risk of overall cancers (HR=0.78 (0.63-0.96), p=0.02). No association was observed between the number of eating episodes, nighttime fasting duration and the nutritional quality of the last eating episode, with cancer risk. Conclusions: This large cohort study suggests that circadian disruption associated with late time of last food intake may be involved in carcinogenesis at different locations. Beyond nutritional quality of food intake, targeting time of food intake might be interesting in cancer prevention.
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Dates et versions

hal-02736259 , version 1 (02-06-2020)

Identifiants

  • HAL Id : hal-02736259 , version 1
  • PRODINRA : 421942
  • WOS : 000415605302204

Citer

Bernard Srour, Sabine Plancoulaine, Valentina Andreeva, Philippine Fassier, Lucie Lecuyer, et al.. Nutrition and cancer in primary prevention: new insights from circadian regulation. 21. International Congress of Nutrition (ICN), Oct 2017, Buenos Aires, Argentina. Karger, Annals of Nutrition and Metabolism, 71 (Suppl. 2), 1433 p., 2017, IUNS 21st International Congress of Nutrition Buenos Aires, Argentina, October 15–20, 2017. Abstracts. ⟨hal-02736259⟩
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