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Article Dans Une Revue Journal of Clinical Medicine Année : 2020

Psychosocial Impact of Predictive Genetic Testing in Hereditary Heart Diseases: The PREDICT Study

Aurélien Palmyre
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Annick Toutain
Caroline Sawka
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  • PersonId : 1073951
Gipsy Billy
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  • PersonId : 1073953
Krystelle Séné
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  • PersonId : 1073954
Isabelle Denjoy
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  • PersonId : 1073955
Bruno Leheup
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  • PersonId : 1073956
Marc Planes
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Stéphanie Staraci
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Elsa Le Boette
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Claire-Cécile Michon
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Angélique Curjol
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Amine Bekhechi
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  • PersonId : 1073962
Rafik Mansouri
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  • PersonId : 1073963
Ibticem Raji
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  • PersonId : 1073964
Véronique Fressart

Résumé

Predictive genetic testing (PGT) is offered to asymptomatic relatives at risk of hereditary heart disease, but the impact of result disclosure has been little studied. We evaluated the psychosocial impacts of PGT in hereditary heart disease, using self-report questionnaires (including the State-Trait Anxiety Inventory) in 517 adults, administered three times to the prospective cohort (PCo: n = 264) and once to the retrospective cohort (RCo: n = 253). The main motivations for undergoing PGT were "to remove doubt" and "for their children". The level of anxiety increased between pre-test and result appointments (p <0.0001), returned to baseline after the result (PCo), and was moderately elevated at 4.4 years (RCo). Subjects with a history of depression or with high baseline anxiety were more likely to develop anxiety after PGT result (p = 0.004 and p <0.0001, respectively), whatever it was. Unfavourable changes in professional and/or family life were observed in 12.4% (PCo) and 18.7% (RCo) of subjects. Few regrets about PGT were expressed (0.8% RCo, 2.3% PCo). Medical benefit was not the main motivation, which emphasises the role of pre/post-test counselling. When PGT was performed by expert teams, the negative impact was modest, but careful management is required in specific categories of subjects, whatever the genetic test result.
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Dates et versions

hal-02882035 , version 1 (26-06-2020)

Identifiants

Citer

Celine Bordet, Sandrine Brice, Carole Maupain, Estelle Gandjbakhch, Bertrand Isidor, et al.. Psychosocial Impact of Predictive Genetic Testing in Hereditary Heart Diseases: The PREDICT Study. Journal of Clinical Medicine, 2020, 9 (5), pp.1365. ⟨10.3390/jcm9051365⟩. ⟨hal-02882035⟩
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