Clinical predictors of recurrences in bipolar disorders type 1 and 2: A FACE-BD longitudinal study
Bruno Etain
(1, 2, 3)
,
Frank Bellivier
(1, 2)
,
Émilie Olié
(4, 2, 5)
,
Bruno Aouizerate
(2, 6)
,
Valérie Aubin
(2, 7)
,
Raoul Belzeaux
(8, 2)
,
Philippe Courtet
(4, 2, 5)
,
Caroline Dubertret
(9, 2)
,
Raymund Schwan
(10, 2)
,
Paul Roux
(11, 12, 2)
,
Mircea Polosan
(13, 2)
,
Marion Leboyer
(14, 2)
,
Ophélia Godin
(15, 2)
,
Pierre Michel Llorca
(2)
,
Chantal Henry
(2)
,
V. Barteau
(2)
,
S. Bensalem
(2)
,
Hakim Laouamri
(2)
,
Karmene Souryis
(2)
,
Sevan Hotier
(2)
,
Amandine Pelletier
,
J. P. Sanchez
,
E. Saliou
,
C. Hebbache
,
Jean Petrucci
,
L. Willaume
,
E. Bourdin
,
Mathilde Carminati
,
Julia Maruani
,
Emeline Marlinge
,
Julie Meheust
,
Bernard Antoniol
,
Alain Desage
,
Sébastien Gard
,
A. Jutant
,
Katia Mbailara
,
Isabelle Minois
,
Léa Zanouy
,
Charlotte Abettan
,
L. Bardin
,
Aurélie Cazals
,
B. Deffinis
,
Déborah Ducasse
,
Marie Gachet
,
Audrey Henrion
,
E. Martinerie
,
Fanny Molière
,
B. Noisette
,
G. Tarquini
,
Jean Michel Azorin
,
Nadia Correard
,
Julia Lou Consoloni
,
Florence Groppi
,
Lauriane Lescalier
,
Julie Montant
,
M. Rebattu
,
N. Viglianese
,
Renaud F. Cohen
,
Grégory Gross
,
Thomas Schwitzer
,
O. Wajsbrot-Elgrabli
,
Thierry Bougerol
,
Benjamin Fredembach
,
A. Suisse
,
B. Halili
,
Z. Gaoua
,
Anne Sophie Cannavo
(16)
,
Anne Marie Galliot
(16)
,
Isabelle Grévin
(16)
,
Nadja Kayser
(16)
,
G. Liaskovski
(16)
,
Christine Passerieux
(17)
,
Iréna Cussac
,
M. A. Dupont
,
Joséphine Loftus
,
Isabelle Medecin
,
Nicolas Mazer
,
Céline Portalier
,
Claire Scognamiglio
,
A. Bing
1
OPTeN (UMR_S_1144 / U1144) -
Optimisation thérapeutique en Neuropsychopharmacologie
2 Fondation FondaMental [Créteil]
3 Hôpital Fernand Widal
4 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
5 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
6 NutriNeuro - Nutrition et Neurobiologie intégrée
7 Centre Hospitalier Princesse Grace
8 INT - Institut de Neurosciences de la Timone
9 Medico-surgical ICU, Assistance Publique - Hôpitaux de Paris, DMU ESPRIT, Médecine Intensive Réanimation, Hôpital Louis Mourier, 92700, Colombes
10 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
11 HANDIReSP - Laboratoire de recherches cliniques et en santé publique sur les handicaps psychique, cognitif et moteur
12 CESP - Centre de recherche en épidémiologie et santé des populations
13 Inserm, U1216, Grenoble, France.
14 DHU PePsy - Psychiatrie et Neurologie personnalisées [AP-HP Hôpital Henri-Mondor]
15 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
16 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
17 CHV - Centre Hospitalier de Versailles André Mignot
2 Fondation FondaMental [Créteil]
3 Hôpital Fernand Widal
4 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
5 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
6 NutriNeuro - Nutrition et Neurobiologie intégrée
7 Centre Hospitalier Princesse Grace
8 INT - Institut de Neurosciences de la Timone
9 Medico-surgical ICU, Assistance Publique - Hôpitaux de Paris, DMU ESPRIT, Médecine Intensive Réanimation, Hôpital Louis Mourier, 92700, Colombes
10 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
11 HANDIReSP - Laboratoire de recherches cliniques et en santé publique sur les handicaps psychique, cognitif et moteur
12 CESP - Centre de recherche en épidémiologie et santé des populations
13 Inserm, U1216, Grenoble, France.
14 DHU PePsy - Psychiatrie et Neurologie personnalisées [AP-HP Hôpital Henri-Mondor]
15 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
16 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
17 CHV - Centre Hospitalier de Versailles André Mignot
Bruno Etain
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- Function : Correspondent author
- PersonId : 757741
- IdHAL : bruno-etain
- ORCID : 0000-0002-5377-1488
- IdRef : 074181106
Connectez-vous pour contacter l'auteur
Frank Bellivier
- Function : Author
- PersonId : 757742
- ORCID : 0000-0002-3660-6640
- IdRef : 070265062
Bruno Aouizerate
- Function : Author
- PersonId : 751079
- IdHAL : bruno-aouizerate
- ORCID : 0000-0002-7092-7747
- IdRef : 069471851
Raoul Belzeaux
- Function : Author
- PersonId : 774517
- ORCID : 0000-0003-1222-6050
Philippe Courtet
- Function : Author
- PersonId : 833371
- ORCID : 0000-0002-6519-8586
- IdRef : 060385022
Raymund Schwan
- Function : Author
- PersonId : 765370
- ORCID : 0000-0002-1059-5584
- IdRef : 074747770
Marion Leboyer
- Function : Author
- PersonId : 756830
- ORCID : 0000-0001-5473-3697
- IdRef : 089352475
Ophélia Godin
- Function : Author
- PersonId : 1093297
- IdHAL : ophelia-godin
- ORCID : 0000-0001-5004-5475
Amandine Pelletier
- Function : Author
- PersonId : 751809
- IdHAL : amandine-pelletier
- ORCID : 0000-0001-7587-0885
- IdRef : 168153068
J. P. Sanchez
- Function : Author
E. Saliou
- Function : Author
C. Hebbache
- Function : Author
Jean Petrucci
- Function : Author
L. Willaume
- Function : Author
E. Bourdin
- Function : Author
Mathilde Carminati
- Function : Author
Julia Maruani
- Function : Author
Emeline Marlinge
- Function : Author
Julie Meheust
- Function : Author
Bernard Antoniol
- Function : Author
Alain Desage
- Function : Author
Sébastien Gard
- Function : Author
A. Jutant
- Function : Author
Katia Mbailara
- Function : Author
Isabelle Minois
- Function : Author
Léa Zanouy
- Function : Author
Charlotte Abettan
- Function : Author
L. Bardin
- Function : Author
Aurélie Cazals
- Function : Author
- PersonId : 754745
- IdHAL : aurelie-cazals
- ORCID : 0000-0002-4907-8568
B. Deffinis
- Function : Author
Déborah Ducasse
- Function : Author
- PersonId : 793831
- ORCID : 0000-0003-3874-5748
- IdRef : 16523833X
Marie Gachet
- Function : Author
Audrey Henrion
- Function : Author
E. Martinerie
- Function : Author
Fanny Molière
- Function : Author
B. Noisette
- Function : Author
G. Tarquini
- Function : Author
Jean Michel Azorin
- Function : Author
Nadia Correard
- Function : Author
Julia Lou Consoloni
- Function : Author
Florence Groppi
- Function : Author
Lauriane Lescalier
- Function : Author
Julie Montant
- Function : Author
M. Rebattu
- Function : Author
N. Viglianese
- Function : Author
Renaud F. Cohen
- Function : Author
- PersonId : 6625
- IdHAL : renaud-f-cohen
- ORCID : 0000-0001-6900-7786
- IdRef : 188924957
Grégory Gross
- Function : Author
Thomas Schwitzer
- Function : Author
- PersonId : 781837
- IdRef : 193732262
O. Wajsbrot-Elgrabli
- Function : Author
Thierry Bougerol
- Function : Author
Benjamin Fredembach
- Function : Author
A. Suisse
- Function : Author
B. Halili
- Function : Author
Z. Gaoua
- Function : Author
Iréna Cussac
- Function : Author
M. A. Dupont
- Function : Author
Joséphine Loftus
- Function : Author
Isabelle Medecin
- Function : Author
Nicolas Mazer
- Function : Author
Céline Portalier
- Function : Author
Claire Scognamiglio
- Function : Author
A. Bing
- Function : Author
Abstract
Objective: To examine which characteristics predict the time to a first mood recurrence at three years in Bipolar Disorder type I (BD-I) and type II (BD-II). Methods: Individuals with BD were followed up to 3 years. Turbull's extension of the Kaplan-Meier analysis for interval-censored data was used to estimate the cumulative probability of recurrence over time. Separate models were performed according to BD subtype to determine which baseline factors were predictive of recurrences and were adjusted for age, gender and educational level. Results: We included 630 individuals with BD-I and 505 with BD-II. The first recurrence of any polarity occurred earlier in BD-II (p = 0.03). The first depressive recurrence occurred earlier in BD-II (p < 0.0001), whereas the first (hypo)manic recurrence occurred earlier in BD-I (p = 0.0003). In BD-I, the clinical variables that were associated to the time to a first mood recurrence were depressive symptoms, lifetime rapid cycling, global activation and the number of psychotropic medications at baseline. In BD-II, the time to a first recurrence was associated with a younger age at onset of BD and a higher number of lifetime mood episodes. The Areas Under the Curve for both models were moderate. Conclusion: Predictors of recurrences showed few specificities to BD-I or BD-II. The ability to predict recurrences in BD based on socio-demographic and clinical variables remained too moderate for a transfer in daily practice. This study highlights the need for further studies that would include other types of predictors, such as molecular, cognitive or neuro-imaging ones, to achieve an accurate level of prediction of recurrences in BD.
Origin : Files produced by the author(s)