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Journal Articles Journal of Psychiatric Research Year : 2021

Clinical predictors of recurrences in bipolar disorders type 1 and 2: A FACE-BD longitudinal study

Bruno Etain (1, 2, 3) , Frank Bellivier (1, 2) , Émilie Olié (4, 2, 5) , Bruno Aouizerate (2, 6) , Valérie Aubin (2, 7) , Raoul Belzeaux (8, 2) , Philippe Courtet (4, 2, 5) , Caroline Dubertret (9, 2) , Raymund Schwan (10, 2) , Paul Roux (11, 12, 2) , Mircea Polosan (13, 2) , Marion Leboyer (14, 2) , Ophélia Godin (15, 2) , Pierre Michel Llorca (2) , Chantal Henry (2) , V. Barteau (2) , S. Bensalem (2) , Hakim Laouamri (2) , Karmene Souryis (2) , Sevan Hotier (2) , Amandine Pelletier , J. P. Sanchez , E. Saliou , C. Hebbache , Jean Petrucci , L. Willaume , E. Bourdin , Mathilde Carminati , Julia Maruani , Emeline Marlinge , Julie Meheust , Bernard Antoniol , Alain Desage , Sébastien Gard , A. Jutant , Katia Mbailara , Isabelle Minois , Léa Zanouy , Charlotte Abettan , L. Bardin , Aurélie Cazals , B. Deffinis , Déborah Ducasse , Marie Gachet , Audrey Henrion , E. Martinerie , Fanny Molière , B. Noisette , G. Tarquini , Jean Michel Azorin , Nadia Correard , Julia Lou Consoloni , Florence Groppi , Lauriane Lescalier , Julie Montant , M. Rebattu , N. Viglianese , Renaud F. Cohen , Grégory Gross , Thomas Schwitzer , O. Wajsbrot-Elgrabli , Thierry Bougerol , Benjamin Fredembach , A. Suisse , B. Halili , Z. Gaoua , Anne Sophie Cannavo (16) , Anne Marie Galliot (16) , Isabelle Grévin (16) , Nadja Kayser (16) , G. Liaskovski (16) , Christine Passerieux (17) , Iréna Cussac , M. A. Dupont , Joséphine Loftus , Isabelle Medecin , Nicolas Mazer , Céline Portalier , Claire Scognamiglio , A. Bing
Amandine Pelletier
J. P. Sanchez
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E. Saliou
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C. Hebbache
  • Function : Author
Jean Petrucci
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L. Willaume
  • Function : Author
E. Bourdin
  • Function : Author
Mathilde Carminati
  • Function : Author
Julia Maruani
  • Function : Author
Emeline Marlinge
  • Function : Author
Julie Meheust
  • Function : Author
Bernard Antoniol
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Alain Desage
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Sébastien Gard
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A. Jutant
  • Function : Author
Katia Mbailara
  • Function : Author
Isabelle Minois
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Léa Zanouy
  • Function : Author
Charlotte Abettan
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L. Bardin
  • Function : Author
Aurélie Cazals
B. Deffinis
  • Function : Author
Déborah Ducasse
Marie Gachet
  • Function : Author
Audrey Henrion
  • Function : Author
E. Martinerie
  • Function : Author
Fanny Molière
  • Function : Author
B. Noisette
  • Function : Author
G. Tarquini
  • Function : Author
Jean Michel Azorin
  • Function : Author
Nadia Correard
  • Function : Author
Julia Lou Consoloni
  • Function : Author
Florence Groppi
  • Function : Author
Lauriane Lescalier
  • Function : Author
Julie Montant
  • Function : Author
M. Rebattu
  • Function : Author
N. Viglianese
  • Function : Author
Renaud F. Cohen
Grégory Gross
  • Function : Author
Thomas Schwitzer
  • Function : Author
  • PersonId : 781837
  • IdRef : 193732262
O. Wajsbrot-Elgrabli
  • Function : Author
Thierry Bougerol
  • Function : Author
Benjamin Fredembach
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A. Suisse
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B. Halili
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Z. Gaoua
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Iréna Cussac
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M. A. Dupont
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Joséphine Loftus
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Isabelle Medecin
  • Function : Author
Nicolas Mazer
  • Function : Author
Céline Portalier
  • Function : Author
Claire Scognamiglio
  • Function : Author
A. Bing
  • Function : Author

Abstract

Objective: To examine which characteristics predict the time to a first mood recurrence at three years in Bipolar Disorder type I (BD-I) and type II (BD-II). Methods: Individuals with BD were followed up to 3 years. Turbull's extension of the Kaplan-Meier analysis for interval-censored data was used to estimate the cumulative probability of recurrence over time. Separate models were performed according to BD subtype to determine which baseline factors were predictive of recurrences and were adjusted for age, gender and educational level. Results: We included 630 individuals with BD-I and 505 with BD-II. The first recurrence of any polarity occurred earlier in BD-II (p = 0.03). The first depressive recurrence occurred earlier in BD-II (p < 0.0001), whereas the first (hypo)manic recurrence occurred earlier in BD-I (p = 0.0003). In BD-I, the clinical variables that were associated to the time to a first mood recurrence were depressive symptoms, lifetime rapid cycling, global activation and the number of psychotropic medications at baseline. In BD-II, the time to a first recurrence was associated with a younger age at onset of BD and a higher number of lifetime mood episodes. The Areas Under the Curve for both models were moderate. Conclusion: Predictors of recurrences showed few specificities to BD-I or BD-II. The ability to predict recurrences in BD based on socio-demographic and clinical variables remained too moderate for a transfer in daily practice. This study highlights the need for further studies that would include other types of predictors, such as molecular, cognitive or neuro-imaging ones, to achieve an accurate level of prediction of recurrences in BD.
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hal-03141485 , version 1 (02-01-2023)

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Attribution - NonCommercial

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Bruno Etain, Frank Bellivier, Émilie Olié, Bruno Aouizerate, Valérie Aubin, et al.. Clinical predictors of recurrences in bipolar disorders type 1 and 2: A FACE-BD longitudinal study. Journal of Psychiatric Research, 2021, 134, pp.129-137. ⟨10.1016/j.jpsychires.2020.12.041⟩. ⟨hal-03141485⟩
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