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Article Dans Une Revue European Journal of Immunology Année : 2021

The "French Germinal Center Club" of the French Society for Immunology

Résumé

The antibody response and B cell memory development are major effector arms of the immune system. They both rely on the selection of B cells in specific anatomical structures called germinal centers (GC). GCs are not only sites for clonal B cell expansion but also the places where the antibody repertoire diversifies following somatic hypermutations and class switch recombination. CD4+ T cells that are present in GCs guide the stringent cell selection of high-affinity B cell variants. They can be divided in two functional cell subsets: T follicular helper (Tfh) and T follicular regulatory (Tfr) cells. Furthermore, follicular B and T cell subsets are in close contact with specialized stromal cells allowing cell migration, adhesion, and participating in B cell selection mechanisms. Importantly, on top of their essential role as orchestrators of protective immune responses against infections, GCs have also been involved in diverse pathological conditions including autoimmunity, allergy, and cancer. The great complexity of these structures means that GC aficionados encompass researchers working on a very large palette of topics including in depth analysis of the immune cell types cited above, characterization of cell interactions between GC immune and/or mesenchymal cell subsets, as well as deciphering disease physiopathology. The great versatility of these research foci means that the GC field is extremely dynamic and multidisciplinary. However, because there are many scientific topics addressed when studying GC and despite a consequent number of teams interested in this field, events centered only on GCs allowing researcher interactions are quite rare.
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Dates et versions

hal-03169542 , version 1 (01-06-2021)

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Patricia Ame, Helene Dumortier, Marion Espeli, Pierre Milpied, Nicolas Fazilleau. The "French Germinal Center Club" of the French Society for Immunology: a dynamic collaboration between researchers passionate about the germinal center reaction. European Journal of Immunology, 2021, 51 (2), pp.270-271. ⟨10.1002/eji.202170025⟩. ⟨hal-03169542⟩
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