%0 Journal Article %T Relationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population %+ Toulouse Neuro Imaging Center (ToNIC) %+ Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL) %+ Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] %+ Université Paris Cité (UPCité) %+ [GIN] Grenoble Institut des Neurosciences (GIN) %+ Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ) %+ Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC) %+ Nutrition et Neurobiologie intégrée (NutriNeuro) %+ Institut Mondor de Recherche Biomédicale (IMRB) %A Yrondi, Antoine %A Arbus, Christophe %A Bennabi, Djamila %A D’amato, Thierry %A Bellivier, Frank %A Bougerol, Thierry %A Camus, Vincent %A Courtet, Philippe %A Doumy, Olivier %A Genty, Jean-Baptiste %A Holtzmann, Jérôme %A Horn, Mathilde %A Lancon, Christophe %A Leboyer, Marion %A Llorca, Pierre-Michel %A Maruani, Julia %A Moirand, Rémi %A Molière, Fanny %A Petrucci, Jean %A Richieri, Raphaelle %A Samalin, Ludovic %A Stephan, Florian %A Vaiva, Guillaume %A Walter, Michel %A Haffen, Emmanuel %A Aouizerate, Bruno %A El-Hage, Wissam %< avec comité de lecture %@ 1932-6203 %J PLoS ONE %I Public Library of Science %V 16 %N 4 %P e0250148 %8 2021 %D 2021 %R 10.1371/journal.pone.0250148 %M 33878137 %Z Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health %Z Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X Introduction We assessed the correlation between childhood maltreatment (CM) and severity of depression in an elderly unipolar Treatment-Resistant Depression (TRD) sample. Methods Patients were enrolled from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centres.Results Our sample included 96 patients (33% of the overall cohort) aged 60 years or above, with a mean age of 67.2 (SD = 5.7). The majority of the patients were female (62.5%). The Montgomery and Asberg Depression Rating Scale (MADRS) and Quick Inventory Depression Scale-Self Report (QIDS-SR) mean scores were high, 28.2 (SD = 7.49) [MADRS score range: 0–60; moderate severity≥20, high severity≥35] and 16.5 (SD = 4.94) [IDS-SR score range: 0–27; moderate severity≥11, high severity≥16], respectively. Mean self-esteem scores were 22.47 (SD = 6.26) [range 0–30]. In an age- and sex-adjusted model, we found a positive correlation between childhood trauma (CTQ scores) and depressive symptom severity [MADRS (β = 0.274; p = 0.07) and QIDS-SR (β = 0.302; p = 0.005) scores]. We detected a statistically significant correlation between physical abuse and depressive symptom severity [MADRS (β = 0.304; p = 0.03) and QIDS-SR (β = 0.362; p = 0.005) scores]. We did not observe any significant correlation between other types of trauma and depressive symptom severity. We showed that self-esteem (Rosenberg scale) mediated the effect of physical abuse (PA) on the intensity of depressive symptoms [MADRS: b = 0.318, 95% BCa C . I . [0.07, 0.62]; QIDS-SR: b = 0.177, 95% BCa C . I . [0.04, 0.37]]. Preacher & Kelly’s Kappa Squared values of 19.1% ( k 2 = 0.191) and 16% ( k 2 = 0.16), respectively for the two scales, indicate a moderate effect.Conclusion To our knowledge, this is the first study conducted in a geriatric TRD population documenting an association between childhood trauma (mainly relating to PA) and the intensity of depressive symptoms. %G English %2 https://u-paris.hal.science/hal-03239839/document %2 https://u-paris.hal.science/hal-03239839/file/journal.pone.0250148.pdf %L hal-03239839 %U https://u-paris.hal.science/hal-03239839 %~ UNIV-ST-ETIENNE %~ UNIV-TLSE2 %~ UNIV-TLSE3 %~ UGA %~ UNIV-TOURS %~ CNRS %~ UNIV-LYON1 %~ UNIV-MONTP1 %~ APHP %~ SANTE_PUB_INSERM %~ IMRB %~ UPEC %~ U1061 %~ BS %~ UNIV-MONTPELLIER %~ UDL %~ UNIV-LYON %~ INRAE %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ TEST-HALCNRS %~ UGA-EPE %~ ANR %~ NUTRINEURO %~ CRNL %~ PSYR2_CRNL %~ UNIV-UT3 %~ UT3-INP %~ UT3-TOULOUSEINP %~ UM-2015-2021 %~ TEST3-HALCNRS %~ TONIC %~ RESEAU-EAU