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Article Dans Une Revue Frontiers in Immunology Année : 2021

Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy

Résumé

Background: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. A clinical series of Kawasaki-like multisystem inflammatory syndrome (MIS), occurring after SARS-CoV-2 infection, have been described in children (MIS-C) and adults (MIS-A), but the pathophysiology remains unknown. Case Presentation: We describe a case of post-COVID-19 MIS-A in a 46-year-old man with biopsy-proven renal thrombotic microangiopathy (TMA). Specific complement inhibition with eculizumab was initiated promptly and led to a dramatic improvement of renal function. Conclusion: Our case suggests that that TMA could play a central role in the pathophysiology of post-COVID-19 MIS-A, making complement blockers an interesting therapeutic option.
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Dates et versions

hal-03285779 , version 1 (13-07-2021)

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Idris Boudhabhay, Marion Rabant, Lubka T Roumenina, Louis-Marie Coupry, Victoria Poillerat, et al.. Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy. Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.680567⟩. ⟨hal-03285779⟩
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