Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children
Nikos Stratakis
(1, 2)
,
David V. Conti
(1)
,
Ran Jin
(1)
,
Katerina Margetaki
(1)
,
Damaskini Valvi
(3)
,
Alexandros Siskos
(4)
,
Léa Maitre
(5, 6, 7)
,
Erika Garcia
(1)
,
Nerea Varo
(8)
,
Yinqi Zhao
(1)
,
Theano Roumeliotaki
(9)
,
Marina Vafeiadi
(9)
,
Jose Urquiza
(5, 6, 7)
,
Silvia Fernández‐barrés
(5, 6, 7)
,
Barbara Heude
(10)
,
Xavier Basagana
(5, 6, 7)
,
Maribel Casas
(5, 6, 7)
,
Serena Fossati
(5, 6, 7)
,
Regina Gražulevičienė
(11)
,
Sandra Andrušaitytė
(11)
,
Karan Uppal
(12)
,
Rosemary R.C. Mceachan
(13)
,
Eleni Papadopoulou
(14)
,
Oliver Robinson
(4)
,
Line Småstuen Haug
(14)
,
John Wright
(13)
,
Miriam Vos
(15, 12)
,
Hector Keun
(4)
,
Martine Vrijheid
(5, 6, 7)
,
Kiros Berhane
(1)
,
Rob Mcconnell
(1)
,
Lida Chatzi
(1, 16)
1
Keck School of Medicine [Los Angeles]
2 Maastricht University [Maastricht]
3 MSSM - Icahn School of Medicine at Mount Sinai [New York]
4 Imperial College London
5 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
6 UPF - Universitat Pompeu Fabra [Barcelona]
7 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
8 Laboratory of Biochemistry
9 UOC - University of Crete [Heraklion]
10 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
11 VDU - Vytautas Magnus University - Vytauto Didziojo Universitetas
12 Emory University School of Medicine
13 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
14 NIPH - Norwegian Institute of Public Health [Oslo]
15 Children’s Healthcare of Atlanta
16 Caphri Research Institute [Maastricht University]
2 Maastricht University [Maastricht]
3 MSSM - Icahn School of Medicine at Mount Sinai [New York]
4 Imperial College London
5 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
6 UPF - Universitat Pompeu Fabra [Barcelona]
7 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
8 Laboratory of Biochemistry
9 UOC - University of Crete [Heraklion]
10 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
11 VDU - Vytautas Magnus University - Vytauto Didziojo Universitetas
12 Emory University School of Medicine
13 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
14 NIPH - Norwegian Institute of Public Health [Oslo]
15 Children’s Healthcare of Atlanta
16 Caphri Research Institute [Maastricht University]
Erika Garcia
- Fonction : Auteur
- PersonId : 806059
- ORCID : 0000-0003-1540-9805
Barbara Heude
- Fonction : Auteur
- PersonId : 739512
- IdHAL : barbaraheude
- ORCID : 0000-0002-1565-1629
- IdRef : 083324593
Martine Vrijheid
- Fonction : Auteur
- PersonId : 763761
- ORCID : 0000-0002-7090-1758
- IdRef : 225451581
Lida Chatzi
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- Fonction : Auteur correspondant
- PersonId : 1107087
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Résumé
Background and Aims:
Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been shown to have hepatotoxic effects in animal models. However, human evidence is scarce. We evaluated how prenatal exposure to PFAS associates with established serum biomarkers of liver injury and alterations in serum metabolome in children.
Approach and Results; We used data from 1,105 mothers and their children (median age, 8.2 years; interquartile range, 6.6-9.1) from the European Human Early-Life Exposome cohort (consisting of six existing population-based birth cohorts in France, Greece, Lithuania, Norway, Spain, and the United Kingdom). We measured concentrations of perfluorooctane sulfonate, perfluorooctanoate, perfluorononanoate, perfluorohexane sulfonate, and perfluoroundecanoate in maternal blood. We assessed concentrations of alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyltransferase in child serum. Using Bayesian kernel machine regression, we found that higher exposure to PFAS during pregnancy was associated with higher liver enzyme levels in children. We also measured child serum metabolomics through a targeted assay and found significant perturbations in amino acid and glycerophospholipid metabolism associated with prenatal PFAS. A latent variable analysis identified a profile of children at high risk of liver injury (odds ratio, 1.56; 95% confidence interval, 1.21-1.92) that was characterized by high prenatal exposure to PFAS and increased serum levels of branched-chain amino acids (valine, leucine, and isoleucine), aromatic amino acids (tryptophan and phenylalanine), and glycerophospholipids (phosphatidylcholine [PC] aa C36:1 and Lyso-PC a C18:1).
Conclusions; Developmental exposure to PFAS can contribute to pediatric liver injury.