Spectrum and Incidence Trends of AIDS- and Non–AIDS-Defining Cancers between 2010 and 2015 in the French Dat'AIDS Cohort
Isabelle Poizot-Martin
(1, 2)
,
Caroline Lions
(3, 2)
,
Clotilde Allavena
(4)
,
Thomas Huleux
(5)
,
Firouze Bani-Sadr
(6)
,
Antoine Cheret
(7)
,
David Rey
(8)
,
Claudine Duvivier
(9, 10, 11)
,
Christine Jacomet
(12)
,
Tristan Ferry
(13, 14)
,
André Cabie
(15, 16)
,
Anne Fresard
(17)
,
Pascal Pugliese
(18, 19)
,
Pierre Delobel
(20)
,
Isabelle Lamaury
(21)
,
Catherine Chirouze
(22)
,
Olivia Zaegel-Faucher
(3, 2)
,
Sylvie Brégigeon
(3, 2)
,
Teresa Rojas Rojas
(3, 2)
,
Véronique Obry-Roguet
(3, 2)
,
Alain Makinson
(23, 24)
1
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
2 Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
3 AMU - Aix Marseille Université
4 Hôtel-Dieu de Nantes
5 Centre Hospitalier Gustave Dron [Tourcoing]
6 Hôpital universitaire Robert Debré [Reims]
7 EA 7327 - Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV)
8 Le Trait d'Union, centre de soins de l'infection par le VIH [CHU Strasbourg]
9 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
10 IC UM3 (UMR 8104 / U1016) - Institut Cochin
11 CMIP - Centre Médical de l'Institut Pasteur
12 CHU Clermont-Ferrand
13 HCL - Hospices Civils de Lyon
14 UCBL - Université Claude Bernard Lyon 1
15 MAITC EA 4537 - Maladies infectieuses et tropicales dans la Caraïbe
16 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
17 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
18 UniCA - Université Côte d'Azur
19 CHU Nice - Centre Hospitalier Universitaire de Nice
20 CPTP - Centre de Physiopathologie Toulouse Purpan
21 CHU Pointe-à-Pitre/Abymes [Guadeloupe]
22 Hôpital JeanMinjoz
23 Infectious and Tropical Diseases Department [Montpellier]
24 GReCSS - IRD UMI233
2 Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
3 AMU - Aix Marseille Université
4 Hôtel-Dieu de Nantes
5 Centre Hospitalier Gustave Dron [Tourcoing]
6 Hôpital universitaire Robert Debré [Reims]
7 EA 7327 - Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV)
8 Le Trait d'Union, centre de soins de l'infection par le VIH [CHU Strasbourg]
9 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
10 IC UM3 (UMR 8104 / U1016) - Institut Cochin
11 CMIP - Centre Médical de l'Institut Pasteur
12 CHU Clermont-Ferrand
13 HCL - Hospices Civils de Lyon
14 UCBL - Université Claude Bernard Lyon 1
15 MAITC EA 4537 - Maladies infectieuses et tropicales dans la Caraïbe
16 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
17 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
18 UniCA - Université Côte d'Azur
19 CHU Nice - Centre Hospitalier Universitaire de Nice
20 CPTP - Centre de Physiopathologie Toulouse Purpan
21 CHU Pointe-à-Pitre/Abymes [Guadeloupe]
22 Hôpital JeanMinjoz
23 Infectious and Tropical Diseases Department [Montpellier]
24 GReCSS - IRD UMI233
Isabelle Poizot-Martin
- Fonction : Auteur
- PersonId : 21118
- IdHAL : isabelle-poizot-martin
- ORCID : 0000-0002-5676-5411
- IdRef : 059519045
Caroline Lions
- Fonction : Auteur
- PersonId : 21118
- IdHAL : isabelle-poizot-martin
- ORCID : 0000-0002-5676-5411
- IdRef : 059519045
Clotilde Allavena
- Fonction : Auteur
- PersonId : 765804
- ORCID : 0000-0003-1010-1270
Catherine Chirouze
- Fonction : Auteur
- PersonId : 760630
- ORCID : 0000-0002-6150-2376
- IdRef : 058486186
Teresa Rojas Rojas
- Fonction : Auteur
Alain Makinson
- Fonction : Auteur
- PersonId : 778550
- ORCID : 0000-0003-2817-8444
Résumé
Background: Cancer risk is higher in people living with HIV (PLWH) compared with the general population, and cancers related to age are expected to be most prevalent.
Methods: We determined the spectrum and incidence rates of AIDS-defining cancers (ADC) and non-AIDS-defining cancers (NADC) and of lung, Hodgkin lymphoma (HL), head and neck (HNC), colon-rectum, anal, liver, breast, prostate, and urinary bladder cancers between January 2010 and December 2015 in the French Dat'AIDS cohort. Incidence rates were calculated by year and compared using the χ 2 test for linear trend. Standardized incidence ratios [SIR (95% confidence interval)] were calculated relative to the French general population.
Results: Among 44,642 patients, corresponding to 180,216.4 person-years (PY), 1,440 cancer cases occurred in 1,314 patients. ADC incidence was 191.4 (172.3-212.7)/105 PY and declined over time overall and in men, whereas NADC incidence was higher [548.8 (515.6-584.1)/105 PY] and did not change. In men, non-Hodgkin lymphoma was the most common cancer, but prostate cancer had the highest incidence among NADCs. Breast cancer was the most common cancer in women. SIRs were higher for cervical cancer [1.93 (1.18-3.14)], HNC in women [2.4 (1.4-4.2)], liver [overall: 3.8 (3.1-4.6); men: 3.2 (2.5-4.0); women: 12.9 (8.3-20.0)], and HL [overall: 13.8 (11.1-17.1); men: 16.2 (12.9-20.4); women: 6.2 (3.22-11.9)] but lower for lung [overall: 0.7 (0.6-0.9); men: 0.7 (0.5-0.8)], prostate [0.6 (0.5-0.7)], and breast cancers [0.6 (0.4-0.7)].
Conclusions: Spectrum of NADCs has changed, with prostate and breast cancers becoming the most common despite their lower SIR.