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Article Dans Une Revue Nature Année : 2021

A roadmap for the Human Developmental Cell Atlas

Deanne Taylor
Sten Linnarsson
Bruce Aronow
Gary Bader
Pablo Camara
  • Fonction : Auteur
J. Gray Camp
Alain Chédotal
Andrew Copp
Paolo Giacobini
Berthold Göttgens
Guoji Guo
Kylie James
  • Fonction : Auteur
John Marioni
Kerstin Meyer
Kathy Niakan
Mats Nilsson
Aviv Regev
Jennifer Rood
Orit Rozenblatt-Rosen
Rahul Satija
Sarah Teichmann
Roser Vento-Tormo
Simone Webb
Omer Bayraktar
  • Fonction : Auteur
Sam Behjati
  • Fonction : Auteur
Andreas Bosio
  • Fonction : Auteur
Steven Lisgo
Jinyue Liu
  • Fonction : Auteur
Emma Lundberg
  • Fonction : Auteur
Raphael Scharfmann

Résumé

The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.

Dates et versions

hal-03365045 , version 1 (05-10-2021)

Identifiants

Citer

Muzlifah Haniffa, Deanne Taylor, Sten Linnarsson, Bruce Aronow, Gary Bader, et al.. A roadmap for the Human Developmental Cell Atlas. Nature, 2021, 597 (7875), pp.196-205. ⟨10.1038/s41586-021-03620-1⟩. ⟨hal-03365045⟩
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