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Article Dans Une Revue NeuroMolecular Medicine Année : 2021

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Eugene Merzon
Ilan Green
  • Fonction : Auteur
Eitan Okun

Résumé

Abstract The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-03433463 , version 1 (18-07-2023)

Identifiants

Citer

Tomer Illouz, Arya Biragyn, Milana Frenkel-Morgenstern, Orly Weissberg, Alessandro Gorohovski, et al.. Specific Susceptibility to COVID-19 in Adults with Down Syndrome. NeuroMolecular Medicine, 2021, 23 (4), pp.561-571. ⟨10.1007/s12017-021-08651-5⟩. ⟨hal-03433463⟩
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