Serum IgG2 levels predict long-term protection following pneumococcal vaccination in systemic lupus erythematosus (SLE) - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Vaccine Année : 2020

Serum IgG2 levels predict long-term protection following pneumococcal vaccination in systemic lupus erythematosus (SLE)

Résumé

Systemic lupus erythematosus (SLE) patients are at risk for pneumococcal infection. Twenty-one consecutive SLE patients (40[25-75] years) received the sequential PCV13/PPSV23 vaccine and factors associated with long-term protection were analyzed. Immune protection, defined by an antigen-specific IgG concentration ≥1.3 µg/mL for at least 70% of 7 pneumococcal serotypes was assessed at baseline, 2, 6, 12 and 36 months defining long-term protection. Only 10 patients showed pneumococcal immune protection 36 months after vaccination. Eleven (52.4%) patients had no long-term protection with a seroconversion that never or only transiently occurred. SLE disease features, treatment received and immunological characteristics did not differ between protected and unprotected patients except for the pre-vaccination IgG2 serum levels. Serum IgG2 level >2.125 µg/ml showed a sensitivity of 100% and a specificity of 90.9% for long-term protection. Sequential pneumococcal vaccination conferred poor immune protection in SLE. Baseline IgG2 serum level identified patients able to benefit from pneumococcal vaccination.
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hal-03494045 , version 1 (17-10-2022)

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Paternité - Pas d'utilisation commerciale

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Anne-Laure Gerard, Tiphaine Goulenok, Mathilde Bahuaud, Chrystelle Francois, Pierre Aucouturier, et al.. Serum IgG2 levels predict long-term protection following pneumococcal vaccination in systemic lupus erythematosus (SLE). Vaccine, 2020, 38, pp.6859 - 6863. ⟨10.1016/j.vaccine.2020.08.065⟩. ⟨hal-03494045⟩
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