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Article Dans Une Revue Nature Immunology Année : 2022

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

1 BRFAA - Biomedical Research Foundation of the Academy of Athens
2 St. Giles Laboratory of Human Genetics of Infectious Diseases
3 Equipe Inserm U1163 - Human genetics of infectious diseases: Complex predisposition
4 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
5 Department of Medecine [Montréal]
6 McGill University = Université McGill [Montréal, Canada]
7 University of Wisconsin-Madison
8 Equipe Inserm U1163 - Human genetics of infectious diseases : Mendelian predisposition
9 Trinity College Dublin
10 University of Rome Tor Vergata
11 Hospital Universitario de Gran Canaria Dr Negrin
12 ULPGC - Universidad de las Palmas de Gran Canaria
13 Ghent University Hospital
14 IDIBELL - Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute
15 ICREA - Institució Catalana de Recerca i Estudis Avançats = Catalan Institution for Research and Advanced Studies
16 CIBER de Enfermedades Raras (CIBERER)
17 UBC - University of British Columbia
18 Karolinska Institutet [Stockholm]
19 Emory University [Atlanta, GA]
20 University of Melbourne
21 USP - Universidade de São Paulo = University of São Paulo
22 UCL - Université Catholique de Louvain = Catholic University of Louvain
23 TAU - Tel Aviv University
24 School of Life Sciences [Lausanne]
25 UNIL - Université de Lausanne = University of Lausanne
26 UoS - University of Sharjah
27 Department of Paediatrics and Adolescent Medicine [HKU]
28 University Hospitals Leuven [Leuven]
29 Department of Microbiology, Immunology and Transplantation [Leuven]
30 Aarhus University Hospital
31 Hiroshima University
32 TMDU - Tokyo Medical and Dental University [Japan]
33 Bilkent University [Ankara]
34 BioNut - Department of Biosciences and Nutrition [Karolinska Insitutet, Sueden]
35 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
36 Génétique Evolutive Humaine - Human Evolutionary Genetics
37 Collège de France - Chaire Génomique humaine et évolution
38 A*STAR - Agency for science, technology and research [Singapore]
39 Nanyang Technological University [Singapour]
40 MED / MUNI - Faculty of Medicine [Brno]
41 Leopold Franzens Universität Innsbruck - University of Innsbruck
42 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
43 UAM - Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań
44 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
45 HHMI - Howard Hughes Medical Institute [New York]
46 University Medical Center [Utrecht]
Elżbieta Kaja
Giuseppe Novelli
Filomeen Haerynck
Carolina Prando
Catherine Biggs
Alexandre Bolze
Anastasiia Bondarenko
  • Fonction : Auteur
Petter Brodin
Carlos Flores
Rabih Halwani
Trine Mogensen
Satoshi Okada
Tayfun Ozcelik
Rebeca Pérez De Diego
  • Fonction : Auteur
Igor Resnick
  • Fonction : Auteur
Anna Sediva
  • Fonction : Auteur
Anna Shcherbina
K. Uddin
  • Fonction : Auteur

Résumé

SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.

Dates et versions

hal-03558195 , version 1 (04-02-2022)

Identifiants

Citer

Evangelos Andreakos, Laurent Abel, Donald Vinh, Elżbieta Kaja, Beth Drolet, et al.. A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection. Nature Immunology, 2022, 23 (2), pp.159-164. ⟨10.1038/s41590-021-01030-z⟩. ⟨hal-03558195⟩
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