Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue (Data Paper) Bipolar Disorders Année : 2022

Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative

1 HMS - Harvard Medical School [Boston]
2 University of Michigan [Ann Arbor]
3 Milken Institute School of Public Health
4 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
5 Centre Hospitalier Princesse Grace
6 APHM - Assistance Publique - Hôpitaux de Marseille
7 INT - Institut de Neurosciences de la Timone
8 IGF - Institut de Génomique Fonctionnelle
9 Deakin University [Burwood]
10 Orygen Youth Health Research Centre [Melbourne]
11 Mayo Clinic [Rochester]
12 YSM - Yale School of Medicine [New Haven, Connecticut]
13 King‘s College London
14 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
15 Hôpital Louis Mourier - AP-HP [Colombes]
16 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
17 Hôpital Lariboisière-Fernand-Widal [APHP]
18 UC San Diego - University of California [San Diego]
19 McLean Hospital [Belmont, Ma.]
20 UNSW - University of New South Wales [Sydney]
21 Centre hospitalier Charles Perrens [Bordeaux]
22 CHU Henri Mondor [Créteil]
23 Fondation FondaMental [Créteil]
24 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
25 UPEC Médecine - Université Paris-Est Créteil Val-de-Marne - Faculté de médecine
26 UBFC - Université Bourgogne Franche-Comté [COMUE]
27 IMRB - Institut Mondor de Recherche Biomédicale
28 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
29 University of Cincinnati College of Medicine
30 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
31 Massachusetts General Hospital [Boston]
32 CHV - Centre Hospitalier de Versailles André Mignot
33 CESP - Centre de recherche en épidémiologie et santé des populations
34 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
35 GIN - [GIN] Grenoble Institut des Neurosciences
36 Case Western Reserve University [Cleveland]
37 CHU Clermont-Ferrand
38 IP - Institut Pascal
39 UL - Université de Lorraine
40 UBC - University of British Columbia
41 UiO - University of Oslo
42 Barwon Health - IMPACT Strategic Research Centre [VIC, Australia]
K. Burdick
C. Millett
J. Biernacka
A. Cleare
J. Fullerton
M. Frye
  • Fonction : Auteur
A. Peters
J. Potter
R. Strawbridge
A. Young
  • Fonction : Auteur
A. Nierenberg

Résumé

Objectives: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. Methods: Thirteen cohorts from 7 countries included n=5,882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived "higher versus lower function" as the dependent variable and selected clinical and demographic variables as predictors. Results: We found high rates of functional impairment, ranging from 41-75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning. Conclusions: The bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients' complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.
Fichier principal
Vignette du fichier
Bipolar Disorders - 2022 - Burdick - Predictors of functional impairment in bipolar disorder Results from 13 cohorts from.pdf (614.73 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03625156 , version 1 (30-05-2022)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

K. Burdick, C. Millett, A. Yocum, C. Altimus, O. Andreassen, et al.. Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative. Bipolar Disorders, 2022, 24 (7), pp.709-719. ⟨10.1111/bdi.13208⟩. ⟨hal-03625156⟩
116 Consultations
81 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More