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Article Dans Une Revue European Journal of Cancer Année : 2022

European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022

1 Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen
2 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
3 University Hospital Schleswig-Holstein [Kiel, Germany]
4 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
5 HIPI (UMR_S_976 / U976) - Immunologie humaine, physiopathologie & immunothérapie
6 AP-HP - Hopital Saint-Louis [AP-HP]
7 OUH - Odense University Hospital
8 King‘s College London
9 ULB - Université libre de Bruxelles
10 CHU Nantes - Centre Hospitalier Universitaire de Nantes
11 CIC Nantes - Centre d’Investigation Clinique de Nantes
12 CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
13 UNIVAQ - University of L'Aquila [Italy]
14 UMPCD - University of Medicine and Pharmacy “Carol Davila” Bucharest
15 AMU - Aix Marseille Université
16 Medizinische Universität Wien = Medical University of Vienna
17 Frankfurt University Hospital
18 MUMC - Maastricht University Medical Centre
19 Aristotle University of Thessaloniki
20 SNMAPE - Shupyk National Medical Academy of Postgraduate Education [Kiev]
21 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
22 Clinic Barcelona Hospital Universitari
23 Hospital Universitario Virgen Macarena [Séville]
24 MV2C - Mount Vernon Cancer Centre [Northwood, UK]
25 University - Hospital of Modena and Reggio Emilia [Modena, Italy]
26 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
27 University of Athens Medical School [Athens]
28 The University of Sydney
29 Centro Hospitalar e Universitário [Coimbra]
30 Università degli studi di Trieste = University of Trieste
31 University of Manchester [Manchester]
Lars Bastholt
Jean-Jacques Grob
Aimilios Lallas

Résumé

Cutaneous melanoma (CM) is potentially the most dangerous form of skin tumor and causes 90% of skin cancer mortality. A unique collaboration of multi-disciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC) was formed to make recommendations on CM diagnosis and treatment, based on systematic literature reviews and the experts' experience. The diagnosis of melanoma can be made clinically and shall always be confirmed with dermatoscopy. If a melanoma is suspected, a histopathological examination is always required. Sequential digital dermatoscopy and full body photography can be used in high-risk patients to improve the detection of early melanoma. Where available, confocal reflectance microscopy can also improve clinical diagnosis in special cases. Melanoma shall be classified according to the 8th version of the American Joint Committee on Cancer classification. Thin melanomas up to 0.8 mm tumor thickness do not require further imaging diagnostics. From stage IB onwards, examinations with lymph node sonography are recommended, but no further imaging examinations. From stage IIC onwards whole-body examinations with computed tomography (CT) or positron emission tomography CT (PET-CT) in combination with brain magnetic resonance imaging are recommended. From stage III and higher, mutation testing is recommended, particularly for BRAF V600 mutation. It is important to provide a structured follow-up to detect relapses and secondary primary melanomas as early as possible. There is no evidence to define the frequency and extent of examinations. A stage-based follow-up scheme is proposed which, according to the experience of the guideline group, covers the optimal requirements, but further studies may be considered. This guideline is valid until the end of 2024.
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Dates et versions

hal-03669608 , version 1 (08-11-2022)

Identifiants

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Claus Garbe, Teresa Amaral, Ketty Peris, Axel Hauschild, Petr Arenberger, et al.. European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022. European Journal of Cancer, 2022, ⟨10.1016/j.ejca.2022.03.008⟩. ⟨hal-03669608⟩
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