Forskolin Induces Endocrine Disturbance in Human JEG-3 Placental Cells - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Toxics Année : 2022

Forskolin Induces Endocrine Disturbance in Human JEG-3 Placental Cells

Résumé

Forskolin, used in folk medicine since ancient times, is now available as a dietary supplement, with an indication as a fat burner and appetite suppressant. However, the safety of forskolin is poorly documented especially for pregnant women. The question that we raised is what about the safety of forskolin in pregnant women? As the placenta, an endocrine organ, is the key organ of pregnancy, we evaluated the in vitro placental toxicity of forskolin. We focused first on the activation of a P2X7 degenerative receptor as a key biomarker for placental toxicity, and second on steroid and peptide hormonal secretion. We observed that forskolin activated P2X7 receptors and disturbed estradiol, progesterone, hPL and hyperglycosylated hCG secretion in human placental JEG-Tox cells. To the best of our knowledge, we highlighted, for the first time, that forskolin induced endocrine disturbance in placental cells. Forskolin does not appear to be a safe product for pregnant women and restrictions should be taken.

Dates et versions

hal-03837745 , version 1 (03-11-2022)

Identifiants

Citer

Patrice Rat, Pascale Leproux, Sophie Fouyet, Elodie Olivier. Forskolin Induces Endocrine Disturbance in Human JEG-3 Placental Cells. Toxics, 2022, 10 (7), pp.355. ⟨10.3390/toxics10070355⟩. ⟨hal-03837745⟩
9 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More