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Pré-Publication, Document De Travail Année : 2023

A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID

Résumé

How novel left-right asymmetries evolve in animals is unknown. Drosophila pachea males display a unique left-right asymmetry in the genital organs and mate in a right-sided position onto the female. In flies, male genitalia undergo a clockwise 360° rotation during development. To test if this tissue remodeling process is linked to asymmetry development in the male genitalia of Drosophila pachea, w e developed CRIPSR and transgenesis in this singular species. As in D. melanogaster , mutants of the MyoID gene homolog undergo reverse rotation of the developing genitalia. In addition, they have mirror-image asymmetric genitalia. Although their genital asymmetry is reversed mutants still adopt a right-sided copulation posture. Our results reveal a novel mechanism for establishing left-right asymmetry in animals, involving complex tissue remodeling and MyoID. One Sentence Summary D. pachea genital left-right size asymmetry is established through MyoID-mediated tissue remodelling and does not determine the direction of mating posture.
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Dates et versions

hal-03848954 , version 1 (02-11-2023)

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Bénédicte Lefèvre, Marine Delvigne, Josué Vidal, Virginie Courtier-Orgogozo, Michael Lang. A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID. 2023. ⟨hal-03848954⟩
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