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Article Dans Une Revue Global Journal of Cancer Therapy Année : 2022

A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets

Tchertanov Luba

Résumé

Receptors Tyrosine Kinases (RTKs) act as sensors for extracellular ligands, the binding of which triggers dimerization, activation, and autophosphorylation of specific tyrosine (Y) residues in the Cytoplasmic Domain (CD). This leads to the recruitment and activation of multiple downstream signaling proteins, which regulate various aspects of cellular physiology.
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Dates et versions

hal-03893814 , version 1 (11-12-2022)

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Tchertanov Luba, Julie Ledoux. A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets. Global Journal of Cancer Therapy, 2022, 8 (1), pp.036-039. ⟨10.17352/2581-5407.000046⟩. ⟨hal-03893814⟩
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