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Article Dans Une Revue International Journal of Molecular Sciences Année : 2019

Melatonin Levels in Preterm and Term Infants and Their Mothers

1 Hôpital Robert Debré
2 BAR - Biomécanique & Appareil Respiratoire
3 U955 Inserm - UPEC - IMRB - "Biomechanics and Respiratory Apparatus" [Créteil]
4 CHI Créteil
5 Service de médecine néonatale et réanimation pédiatrique, CHU de Reims
6 AP-HP Hôpital universitaire Robert-Debré [Paris]
7 Département de Biochimie [AP-HP Hôpital Robert Debré]
8 GHE - Groupement Hospitalier Lyon-Est
9 ACOML - Atmospheric Chemistry Observations and Modeling Laboratory
10 PROTECT - Neuroprotection du Cerveau en Développement / Promoting Research Oriented Towards Early Cns Therapies
11 Centre de recherche en Myologie – U974 SU-INSERM
12 Hôpital Robert Debré Paris
13 URCA - Université de Reims Champagne-Ardenne
14 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
15 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress
16 CRESS - U1153 - Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique
17 UPD5 - Université Paris Descartes - Paris 5
18 CIC 1426 - Centre d'Investigation Clinique 1426
19 ECEVE (U1123 / UMR_S_1123) - Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables
20 Unité d'Epidémiologie clinique [Paris]
21 UPD7 - Université Paris Diderot - Paris 7
22 PRES Sorbonne Paris Cité
23 Service d'Endocrinologie et Diabétologie Pédiatriques [Paris]
24 Centre de Référence des Maladies Endocriniennes Rares de la Croissance [APHP Robert Debré]
25 Service de Pharmacologie Pédiatrique et Pharmacogénétique [Robert Debré, Paris]
26 Hôpital Robert Debré
27 NeuroDiderot (UMR_S_1141 / U1141) - Maladies neurodéveloppementales et neurovasculaires
28 Service de neurologie pédiatrique et maladies métaboliques
Bassam Haddad
  • Fonction : Auteur

Résumé

The prevention of perinatal brain damage following preterm birth remains a public health priority. Melatonin has been shown to be a promising neuroprotectant in neonatal preclinical models of brain damage, but few studies have investigated melatonin secretion in newborns. We hypothesized that melatonin circulating levels would be lower in preterm compared to term infants. We conducted a prospective, longitudinal, multicenter study to assess melatonin, and 6-sulfatoxy-melatonin (aMT6s) concentrations, measured by radioimmunoassay. Among 209 neonates recruited, 110 were born before 34 gestational weeks (GW) and 99 born after 34 GW. Plasma melatonin concentrations, measured at birth and on Day 3 were below detectable levels (≤7 pg/mL) in 78% and 81%, respectively, of infants born before 34 GW compared to 57% and 34%, respectively, of infants born after 34 GW. The distribution of plasma melatonin concentrations was found to be correlated with gestational age at both time-points (p < 0.001). Median urine aMT6s concentrations were significantly lower in infants born before 34 GW, both on Day 1 (230 ng/L vs. 533 ng/L, p < 0.0001) and on Day 3 (197 ng/L vs. 359 ng/L, p < 0.0001). In conclusion, melatonin secretion appears very low in preterm infants, providing the rationale for testing supplemental melatonin as a neuroprotectant in clinical trials.

Dates et versions

hal-03971379 , version 1 (03-02-2023)

Identifiants

Citer

Valérie Biran, Fabrice Decobert, Nathalie Bednarek, Priscilla Boizeau, Jean-François Benoist, et al.. Melatonin Levels in Preterm and Term Infants and Their Mothers. International Journal of Molecular Sciences, 2019, 20 (9), pp.2077. ⟨10.3390/ijms20092077⟩. ⟨hal-03971379⟩
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