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Article Dans Une Revue Paediatric and Perinatal Epidemiology Année : 2018

The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers

Gabriella Tikellis
Ora Paltiel
  • Fonction : Auteur
Gary Phillips
  • Fonction : Auteur
Stanley Lemeshow
  • Fonction : Auteur
Sjurdur Olsen
  • Fonction : Auteur
Mary Ward
  • Fonction : Auteur
Marin Ström
  • Fonction : Auteur
Somdat Mahabir
  • Fonction : Auteur
Rena Jones
  • Fonction : Auteur
Marie Aline Charles
  • Fonction : Auteur
Edwin Trevathan
  • Fonction : Auteur
Zhengmin Min Qian
  • Fonction : Auteur
Milena Maule
  • Fonction : Auteur
Xiu Qiu
Yun-Chul Hong
  • Fonction : Auteur
Silvia Brandelise
  • Fonction : Auteur
Eve Roman
  • Fonction : Auteur
Melissa Wake
  • Fonction : Auteur
Jian-Rong He
  • Fonction : Auteur
Martha Linet

Résumé

Background: Childhood cancer is a rare but leading cause of morbidity and mortality. Established risk factors, accounting for <10% of incidence, have been identified primarily from case-control studies. However, recall, selection and other potential biases impact interpretations particularly, for modest associations. A consortium of pregnancy and birth cohorts (I4C) was established to utilise prospective, pre-diagnostic exposure assessments and biological samples. Methods: Eligibility criteria, follow-up methods and identification of paediatric cancer cases are described for cohorts currently participating or planning future participation. Also described are exposure assessments, harmonisation methods, biological samples potentially available for I4C research, the role of the I4C data and biospecimen coordinating centres and statistical approaches used in the pooled analyses. Results: Currently, six cohorts recruited over six decades (1950s-2000s) contribute data on 388 120 mother-child pairs. Nine new cohorts from seven countries are anticipated to contribute data on 627 500 additional projected mother-child pairs within 5 years. Harmonised data currently includes over 20 "core" variables, with notable variability in mother/child characteristics within and across cohorts, reflecting in part, secular changes in pregnancy and birth characteristics over the decades. Conclusions: The I4C is the first cohort consortium to have published findings on paediatric cancer using harmonised variables across six pregnancy/birth cohorts. Projected increases in sample size, expanding sources of exposure data (eg, linkages to environmental and administrative databases), incorporation of biological measures to clarify exposures and underlying molecular mechanisms and forthcoming joint efforts to complement case-control studies offer the potential for breakthroughs in paediatric cancer aetiologic research

Dates et versions

hal-04043653 , version 1 (23-03-2023)

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Citer

Gabriella Tikellis, Terence Dwyer, Ora Paltiel, Gary Phillips, Stanley Lemeshow, et al.. The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers. Paediatric and Perinatal Epidemiology, 2018, 32 (6), pp.568-583. ⟨10.1111/ppe.12519⟩. ⟨hal-04043653⟩
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